{"id":"W1982970232","doi":"10.1517/13543776.2013.780598","title":"Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 – 2013)","year":2013,"lang":"en","type":"review","venue":"Expert Opinion on Therapeutic Patents","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":295,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McMaster University","keywords":"Carbonic anhydrase; Pharmacology; Chlorthalidone; Chemistry; Furosemide; Diuretic; Hydrochlorothiazide; Bumetanide; Drug; Acetazolamide; Medicine; Internal medicine; Blood pressure; Enzyme; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001524865,0.0006398594,0.0007895319,0.0001114008,0.0001188062,0.00007451331,0.0001652868,0.0005549365,0.00009918643],"category_scores_gemma":[0.00001218936,0.0004320159,0.0002607442,0.000164752,0.00009191885,0.00001476174,0.00007069598,0.0004094336,0.00006573794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006975407,"about_ca_system_score_gemma":0.0001232605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005905185,"about_ca_topic_score_gemma":0.000001928009,"domain_scores_codex":[0.9978071,0.0002892777,0.0004764389,0.0007599393,0.0003040454,0.0003631733],"domain_scores_gemma":[0.9986764,0.00001528155,0.0003469309,0.0006344627,0.0001202073,0.0002067518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007576971,0.000261998,0.000003486984,0.008278318,0.000398864,0.00001248012,0.00004738185,4.980312e-7,0.0004162678,0.00003127282,0.08117785,0.9092958],"study_design_scores_gemma":[0.0004912729,0.0006085711,0.000001984896,0.0388214,0.00006511089,0.0001772216,0.00001216756,0.00000289427,0.0001867833,0.000003117493,0.9591234,0.0005060948],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000011168,0.9972133,0.00004572007,0.0002625528,0.00105359,0.001174647,0.00004052294,0.00003707014,0.0001614509],"genre_scores_gemma":[0.00003202503,0.9934326,0.00004245242,0.002340314,0.0008455915,0.0004997131,0.001658286,0.00009531918,0.001053636],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9087897,"threshold_uncertainty_score":0.9998131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0921937601477758,"score_gpt":0.3382070873180926,"score_spread":0.2460133271703168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}