{"id":"W1982984638","doi":"10.1021/cb400542w","title":"Selectively Targeting Prostate Cancer with Antiandrogen Equipped Histone Deacetylase Inhibitors","year":2013,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Cancer Institute; National Institutes of Health","keywords":"Histone deacetylase; LNCaP; DU145; Prostate cancer; Cancer research; Vorinostat; Antiandrogen; Androgen receptor; Biology; Histone; Acetylation; Cancer; Chemistry; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001790559,0.0003232707,0.0003198178,0.00007698694,0.0001269323,0.00002794436,0.0003094532,0.0003880553,0.00013982],"category_scores_gemma":[0.0002220113,0.0002631159,0.00008755252,0.0002642393,0.0005106599,0.00001259946,0.0002551769,0.0003418183,0.0001269269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001187116,"about_ca_system_score_gemma":0.0002431224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000430124,"about_ca_topic_score_gemma":0.00003094421,"domain_scores_codex":[0.9977475,0.0001187998,0.0003486114,0.0007916861,0.0001753388,0.0008180353],"domain_scores_gemma":[0.9988922,0.00003638518,0.0001363482,0.0003384871,0.0003382644,0.0002582616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001889561,0.00008558139,0.003354599,0.00002172077,0.00009028428,0.000006145147,0.00006893394,0.00000490202,0.977524,0.00001414026,0.01603716,0.00260355],"study_design_scores_gemma":[0.0009754811,0.0003551908,0.00009984004,0.00001863263,0.00001560486,0.00002914238,0.00004114988,0.00001959887,0.9798472,0.00004095732,0.01817951,0.0003777126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962101,0.001715219,0.00006016765,0.0007012449,0.0001017284,0.0005667628,0.000041131,0.00005152286,0.0005521016],"genre_scores_gemma":[0.9966424,0.0001802633,0.0007939381,0.0003158055,0.0004360491,0.0003772639,0.0003946855,0.00006334225,0.0007962286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003254758,"threshold_uncertainty_score":0.9999821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00699813025288969,"score_gpt":0.2778628196197386,"score_spread":0.2708646893668489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}