{"id":"W1982984638","doi":"10.1021/cb400542w","title":"Selectively Targeting Prostate Cancer with Antiandrogen Equipped Histone Deacetylase Inhibitors","year":2013,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Cancer Institute; National Institutes of Health","keywords":"Histone deacetylase; LNCaP; DU145; Prostate cancer; Cancer research; Vorinostat; Antiandrogen; Androgen receptor; Biology; Histone; Acetylation; Cancer; Chemistry; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008263597,0.0003386547,0.0002743882,0.0001809406,0.00008733269,0.0002770379,0.0002518916,0.0002373497,0.001173376],"category_scores_gemma":[0.00004477803,0.000192165,0.0002581531,0.0001694775,0.0001627071,0.0001359506,0.0001740476,0.0004010287,0.000427181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004067663,"about_ca_system_score_gemma":0.0002340024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006018537,"about_ca_topic_score_gemma":0.002274275,"domain_scores_codex":[0.999925,0.000008505288,0.000002713666,0.0000190624,0.0000217909,0.00002280874],"domain_scores_gemma":[0.9999775,0.000003302773,0.000007114442,0.000003247576,0.000002996996,0.000005877966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004689379,0.000031895,0.00004532082,0.00005309998,0.000009058538,0.00002384455,0.000009424385,0.0002856753,0.9950383,0.0003692961,0.0001571777,0.003930035],"study_design_scores_gemma":[0.00001846543,0.0003434344,0.0004269067,0.000003283102,0.00001518271,0.0001022308,0.000005140709,0.0007938953,0.9922052,0.00005030375,0.006031548,0.000004376315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9341909,0.0137089,0.03121452,0.0005373421,0.000165325,0.0002437183,0.0008099089,0.0008661462,0.0182632],"genre_scores_gemma":[0.974088,0.005918599,0.01231291,0.0002122079,0.00002952191,0.00009240604,0.0003560259,0.0000454127,0.006944881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001173376,"threshold_uncertainty_score":0.003925323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00699813025288969,"score_gpt":0.2778628196197386,"score_spread":0.2708646893668489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}