{"id":"W1982992646","doi":"10.1021/ol902767b","title":"Highly Diastereoselective Synthesis of Substituted Pyrrolidines Using a Sequence of Azomethine Ylide Cycloaddition and Nucleophilic Cyclization","year":2010,"lang":"en","type":"article","venue":"Organic Letters","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Azomethine ylide; Cycloaddition; Chemistry; Iminium; Nucleophile; Diastereomer; Ylide; Nucleophilic addition; Adduct; Tin; Combinatorial chemistry; Medicinal chemistry; Stereochemistry; Organic chemistry; Ion; Catalysis; 1,3-Dipolar cycloaddition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001057695,0.0001332034,0.0002409911,0.0001025669,0.00006351917,0.00001545477,0.0001155069,0.0001010096,0.00038391],"category_scores_gemma":[0.0005054272,0.0001285924,0.00005323992,0.0002584928,0.0001663,0.0001862444,0.00002753089,0.0001360811,0.00000288922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004258532,"about_ca_system_score_gemma":0.00003845773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001891657,"about_ca_topic_score_gemma":0.00003161321,"domain_scores_codex":[0.9991737,0.00001561213,0.0002900548,0.000219048,0.0001652968,0.000136258],"domain_scores_gemma":[0.9990681,0.0002736237,0.0002671152,0.0002651656,0.00007847185,0.00004756261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000121547,0.00004130892,0.002139698,0.00008008446,0.00005094014,0.000001898603,0.0002159296,0.000006601505,0.9961998,0.00008346473,0.00001685023,0.001151221],"study_design_scores_gemma":[0.0001454608,0.000003730767,0.004647185,0.00007939512,0.0001130119,0.00003801355,0.00008836254,0.0003111229,0.9943522,0.00006645663,0.00003402829,0.0001210241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989483,0.00001523552,0.0002648743,0.0003669085,0.00007659452,0.00005116034,0.00006771639,0.00003327851,0.0001759515],"genre_scores_gemma":[0.9992176,0.00002335764,0.0005710188,0.00004557161,0.00008597535,0.000006754288,0.00001981701,0.00002457851,0.000005339791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002507487,"threshold_uncertainty_score":0.5243845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01510298775998045,"score_gpt":0.2330577982351545,"score_spread":0.2179548104751741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}