{"id":"W1982994192","doi":"10.1110/ps.062613807","title":"Parathyroid hormone is a heparin/polyanion binding protein: Binding energetics and structure modification","year":2007,"lang":"en","type":"article","venue":"Protein Science","topic":"Bone health and treatments","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nuvo Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Parathyroid hormone; Heparin; Biochemistry; Circular dichroism; Energetics; Protein structure; Biophysics; Crystallography; Calcium; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006955465,0.0001612105,0.0001805884,0.0002770533,0.0004738725,0.00006528986,0.0001146871,0.00009664564,0.000009431266],"category_scores_gemma":[0.0001316903,0.000130763,0.00002357012,0.0008538236,0.0002857545,0.0002547885,0.00006211367,0.0001862559,0.00002163633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001819674,"about_ca_system_score_gemma":0.000221778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001367547,"about_ca_topic_score_gemma":0.00001387434,"domain_scores_codex":[0.9980913,0.0000150328,0.0002767759,0.0004900276,0.0005767257,0.0005501198],"domain_scores_gemma":[0.9990323,0.0000129927,0.0001424397,0.0002976841,0.0001152425,0.0003993389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009604089,0.00005170923,0.00432859,0.00003940054,0.000004802262,0.00001233591,0.0003161244,2.72833e-7,0.9838951,0.0006535474,0.00001581943,0.01058629],"study_design_scores_gemma":[0.001232636,0.0004720671,0.04670471,0.000110796,0.00002261767,0.0000787347,0.0001014613,0.0005680005,0.9494921,0.0004309816,0.0005895417,0.000196365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961745,0.0005446278,0.0007145791,0.0006276264,0.00004171391,0.001449278,0.000008937571,0.00005788206,0.0003808205],"genre_scores_gemma":[0.9887366,0.00003510049,0.0102621,0.00009970928,0.00003554,0.00005183702,0.000008106047,0.0000135952,0.0007574598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04237612,"threshold_uncertainty_score":0.5332362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02841494630296063,"score_gpt":0.3183132576491809,"score_spread":0.2898983113462202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}