{"id":"W1982994560","doi":"10.1007/s10549-009-0621-9","title":"Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer","year":2009,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":161,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Cyclin D1; Cancer research; Cyclin D; JAG1; Cyclin B; Cyclin A2; Notch signaling pathway; Biology; Breast cancer; Cell cycle; Cyclin A; Cyclin; Cancer; Signal transduction; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001557997,0.0001272701,0.000157351,0.000362095,0.0002717235,0.00044149,0.0002397079,0.00018198,0.001533433],"category_scores_gemma":[0.0002140022,0.0001369201,0.0001051637,0.0002011019,0.0001749888,0.0001582831,0.0001710159,0.0003857042,0.0002915562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007076447,"about_ca_system_score_gemma":0.0003166092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008793951,"about_ca_topic_score_gemma":0.002041911,"domain_scores_codex":[0.9999299,0.00001118039,0.000005289819,0.00001502266,0.00002257273,0.00001613481],"domain_scores_gemma":[0.9999465,0.0000106703,0.0000133756,0.000005195899,0.00000797205,0.00001635167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004647759,0.00003796773,0.002426401,0.00008816074,0.00001723343,0.0002879374,0.00002973909,0.000226405,0.986707,0.0009477753,0.0003832272,0.008383325],"study_design_scores_gemma":[0.00004721048,0.0001470357,0.02122281,0.000008298583,0.00002905481,0.001169845,0.00009177188,0.0008674526,0.9642924,0.0003045748,0.0118142,0.000005366615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675474,0.01713165,0.003120783,0.0006641793,0.00008779993,0.00003817219,0.00064903,0.0001091344,0.01065189],"genre_scores_gemma":[0.9946167,0.001554228,0.0005035112,0.00005413178,0.000009689034,0.00001216293,0.0002396081,0.000008607552,0.003001367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001533433,"threshold_uncertainty_score":0.005134344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02505003455872102,"score_gpt":0.347420285084259,"score_spread":0.322370250525538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}