{"id":"W1982994717","doi":"10.1016/j.biochi.2013.12.023","title":"Inactive C-terminal telomerase reverse transcriptase insertion splicing variants are dominant-negative inhibitors of telomerase","year":2014,"lang":"en","type":"article","venue":"Biochimie","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Telomerase; Telomerase reverse transcriptase; Telomere; Biology; Ribonucleoprotein; Telomerase RNA component; Molecular biology; Reverse transcriptase; RNA; Protein subunit; RNA splicing; Alternative splicing; Messenger RNA; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005335321,0.000511046,0.0009567777,0.0005510566,0.0002243419,0.00002714968,0.0002144733,0.0002741679,0.0001791204],"category_scores_gemma":[0.000832139,0.0004550254,0.0002998625,0.0007579845,0.0003722736,0.0003276387,0.00005832128,0.0004630487,0.00007762929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001951477,"about_ca_system_score_gemma":0.0002084474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007040953,"about_ca_topic_score_gemma":0.00007634245,"domain_scores_codex":[0.9968977,0.0002405561,0.0008633787,0.0007623144,0.0006251539,0.0006109049],"domain_scores_gemma":[0.997745,0.0002320336,0.0005403104,0.0006980201,0.0003310915,0.0004535386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003670993,0.001459946,0.0263424,0.0009099061,0.0002246937,0.0005002939,0.003439342,0.000007023512,0.9339818,0.0003078716,0.003600536,0.02555524],"study_design_scores_gemma":[0.00583308,0.001121274,0.1910288,0.001543613,0.0004173452,0.0002883899,0.002253555,0.0003420701,0.7943007,0.0001939435,0.001982585,0.0006946402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960139,0.0001666341,0.0004361227,0.0006896672,0.0006241239,0.0007881012,0.0001102978,0.00009764136,0.001073537],"genre_scores_gemma":[0.9960936,0.0001258265,0.001899134,0.0008437124,0.0004518849,0.00003965603,0.00005526384,0.0000677857,0.0004231352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1646864,"threshold_uncertainty_score":0.9997901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01502041749076173,"score_gpt":0.2506992673856265,"score_spread":0.2356788498948648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}