{"id":"W1983065003","doi":"10.1371/journal.pone.0043990","title":"Liuwei Dihuang (LWDH), a Traditional Chinese Medicinal Formula, Protects against β-Amyloid Toxicity in Transgenic Caenorhabditis elegans","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Prince Edward Island; National Research Council Canada; Nova Scotia Department of Agriculture","funders":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences and Peking Union Medical College; National Research Council Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; China Academy of Chinese Medical Sciences; Department of Agriculture, Nova Scotia","keywords":"Caenorhabditis elegans; Oxidative stress; Reactive oxygen species; Gallic acid; Juglone; DPPH; Biochemistry; Chemistry; Transgene; Pharmacology; Biology; Cell biology; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002961507,0.0002848171,0.0003213342,0.00009515551,0.0001116994,0.00002179013,0.0002567848,0.0002397996,0.00009316259],"category_scores_gemma":[0.000110702,0.0002787829,0.0001175927,0.0001507922,0.0001058919,0.00001996716,0.00004951597,0.0002792156,0.00002443813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005312705,"about_ca_system_score_gemma":0.00009132285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005002792,"about_ca_topic_score_gemma":0.0003054507,"domain_scores_codex":[0.9981765,0.00008239488,0.000338352,0.0003728066,0.0004137124,0.000616213],"domain_scores_gemma":[0.9992273,0.00002135855,0.00008432466,0.0003517595,0.00006581521,0.0002494247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006477789,0.002012594,0.019157,0.0001406063,0.0001537491,0.000005945263,0.001218546,0.00004035795,0.9764895,0.00004208529,0.00009815537,0.0005766965],"study_design_scores_gemma":[0.001901386,0.0006719914,0.08051888,0.0001342796,0.00009324946,0.00002426688,0.00009058823,0.0005113449,0.9145131,0.0003820431,0.0004775645,0.0006813271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948809,0.001085645,0.002182132,0.0003305635,0.0001123856,0.0005705077,0.00008433941,0.00003020431,0.0007232946],"genre_scores_gemma":[0.9954132,0.0002804323,0.001979423,0.0005803859,0.001060321,0.000120607,0.0003081183,0.00004998353,0.0002074941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0619764,"threshold_uncertainty_score":0.9999664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03157706410913501,"score_gpt":0.2197839900280718,"score_spread":0.1882069259189367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}