{"id":"W1983080543","doi":"10.1007/s12640-010-9174-2","title":"Development and Validation of a Screening Assay for the Evaluation of Putative Neuroprotective Agents in the Treatment of Parkinson’s Disease","year":2010,"lang":"en","type":"article","venue":"Neurotoxicity Research","topic":"Coenzyme Q10 studies and effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Neurological Disorders and Stroke; University of Toronto","keywords":"Neuroprotection; Neurodegeneration; Coenzyme Q10; Programmed cell death; Rotenone; Oxidative stress; Parkinson's disease; Proteasome; Pharmacology; Biology; Viability assay; Lysosome; Mitochondrion; Biochemistry; Cell; Medicine; Apoptosis; Disease; Internal medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002144943,0.00006139796,0.00008663382,0.00004390303,0.00009851425,0.000006803034,0.0001023539,0.00002737195,0.000001432388],"category_scores_gemma":[0.0008894936,0.00003673919,0.00003569104,0.00012092,0.0001287725,0.000002516461,0.00005219546,0.00007296671,6.809763e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009313274,"about_ca_system_score_gemma":0.00008374224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005866616,"about_ca_topic_score_gemma":0.0000954284,"domain_scores_codex":[0.9986819,0.0005006518,0.00014201,0.0001646566,0.0003928174,0.0001179849],"domain_scores_gemma":[0.9990784,0.0003323647,0.00006941256,0.000173794,0.000324628,0.00002141655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001069762,0.0005376382,0.01690655,0.00008959429,0.00008008518,9.864953e-7,0.003384257,0.0004173935,0.9247609,0.00003405132,0.0001140378,0.05260471],"study_design_scores_gemma":[0.0007284259,0.0006853484,0.2719665,0.00000768898,0.00001837183,3.854017e-7,0.0002836557,0.002905944,0.7215132,0.00003425428,0.001824915,0.00003136294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971166,0.0001065282,0.0002643979,0.0001623259,0.00001893852,0.002294798,0.00001900757,6.191252e-7,0.00001678818],"genre_scores_gemma":[0.99898,0.00006498832,0.0001593379,0.000008675193,0.00002546897,0.0007390624,0.00001066059,0.000005268796,0.000006541191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2550599,"threshold_uncertainty_score":0.1498181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1640758026019684,"score_gpt":0.4259711637209746,"score_spread":0.2618953611190062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}