{"id":"W1983086187","doi":"10.1007/s10637-005-2905-1","title":"Phase I and pharmacokinetic study of Bay 38-3441, a camptothecin glycoconjugate, administered as a 30-minute infusion daily for five days every 3 weeks in patients with advanced solid malignancies","year":2005,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Bayer (Canada); Ontario Institute for Cancer Research","funders":"","keywords":"Medicine; Camptothecin; Lethargy; Vomiting; Toxicity; Nausea; Pharmacokinetics; Diarrhea; Pharmacology; Gastroenterology; Anesthesia; Internal medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006626871,0.001221678,0.002035808,0.0004433144,0.0004680182,0.0007723171,0.0006717204,0.0008635672,0.00114825],"category_scores_gemma":[0.0009147854,0.000657491,0.0009271499,0.0006245518,0.001102665,0.0007192125,0.0002338676,0.00336345,0.000410187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001047396,"about_ca_system_score_gemma":0.001623554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002678726,"about_ca_topic_score_gemma":0.002953835,"domain_scores_codex":[0.9996934,0.0001228673,0.000009496816,0.00005667216,0.00003958661,0.00007801606],"domain_scores_gemma":[0.9994285,0.00009649596,0.0001137499,0.00006896031,0.00002701272,0.0002652428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4873694,0.07657946,0.009925226,0.0005044611,0.001144948,0.0006188398,0.0007559592,0.01123301,0.2391096,0.001034345,0.006746307,0.1649785],"study_design_scores_gemma":[0.2822357,0.64513,0.03532192,0.00002675317,0.0006816461,0.0009185086,0.0001435855,0.006181268,0.02294718,0.0004128628,0.005927454,0.00007318091],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959689,0.0009362245,0.0006286725,0.0002681177,0.00006781606,0.0005384929,0.0004840676,0.00009166617,0.001016042],"genre_scores_gemma":[0.9955596,0.0008559678,0.00092036,0.0002446778,0.00008277503,0.0004297805,0.0008268576,0.00003995782,0.001040057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002678726,"threshold_uncertainty_score":0.007599473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01063012803762387,"score_gpt":0.2795822471758359,"score_spread":0.268952119138212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}