{"id":"W1983098174","doi":"10.1038/sj.cgt.7700595","title":"Intramuscular gene transfer of soluble B7.1/IgG1 fusion cDNA induces potent antitumor immunity as an adjuvant for DNA vaccination","year":2003,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"DNA vaccination; Electroporation; Immune system; Adjuvant; Fusion protein; Antigen; CTL*; Molecular biology; Biology; Cytotoxic T cell; Carcinoembryonic antigen; Antibody; Adoptive cell transfer; Genetic enhancement; Immunoglobulin G; Fusion gene; Recombinant DNA; Immunology; T cell; Gene; Cancer; In vitro; CD8; Biochemistry; Immunization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004624978,0.0006070296,0.0005969094,0.0008322448,0.0002235005,0.0004278178,0.0003672698,0.0007358368,0.00125648],"category_scores_gemma":[0.0002135173,0.0002979539,0.0003942639,0.0002908738,0.000453278,0.0003144754,0.0002678013,0.00139296,0.0007059853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005757984,"about_ca_system_score_gemma":0.0005126658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009318818,"about_ca_topic_score_gemma":0.001002244,"domain_scores_codex":[0.9996654,0.00004560305,0.00001690355,0.00005451884,0.00006296265,0.0001546854],"domain_scores_gemma":[0.9997885,0.0000738027,0.00003647121,0.00002527195,0.00002388833,0.00005211436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001648358,0.0000924199,0.00005182883,0.00002720264,0.000004176039,0.0000242407,0.00001178675,0.0001152836,0.9980575,0.0001388483,0.00004816537,0.001263602],"study_design_scores_gemma":[0.00006488779,0.0005066532,0.0004296528,0.000004938293,0.0000222523,0.00006959293,0.000009219684,0.001058343,0.9970156,0.0000524981,0.000763289,0.000003010212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871875,0.001769706,0.007491284,0.0002134188,0.0001202978,0.0001228889,0.0002555285,0.0002411974,0.002598263],"genre_scores_gemma":[0.9911731,0.0006469,0.003833194,0.00008156028,0.00005297651,0.00007072145,0.0004093973,0.00004786357,0.003684342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00125648,"threshold_uncertainty_score":0.00420332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05049384806446507,"score_gpt":0.3478016085231401,"score_spread":0.297307760458675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}