{"id":"W1983098174","doi":"10.1038/sj.cgt.7700595","title":"Intramuscular gene transfer of soluble B7.1/IgG1 fusion cDNA induces potent antitumor immunity as an adjuvant for DNA vaccination","year":2003,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"DNA vaccination; Electroporation; Immune system; Adjuvant; Fusion protein; Antigen; CTL*; Molecular biology; Biology; Cytotoxic T cell; Carcinoembryonic antigen; Antibody; Adoptive cell transfer; Genetic enhancement; Immunoglobulin G; Fusion gene; Recombinant DNA; Immunology; T cell; Gene; Cancer; In vitro; CD8; Biochemistry; Immunization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008224422,0.0002664021,0.0005305592,0.0002082946,0.0001770998,0.00002784268,0.0002345404,0.0001692493,0.003639286],"category_scores_gemma":[0.00002934025,0.0002286821,0.0002357147,0.0003495425,0.00006724972,0.0001538915,0.00001531661,0.0002523943,0.000005387811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002400381,"about_ca_system_score_gemma":0.0004396304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004972554,"about_ca_topic_score_gemma":0.00007051938,"domain_scores_codex":[0.9979761,0.0002092185,0.0004158322,0.0004212626,0.0005124902,0.0004650731],"domain_scores_gemma":[0.9985387,0.00004318513,0.00007837141,0.0006619002,0.000470564,0.0002072668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001757837,0.0004529153,0.0003683608,0.00007449732,0.0001974793,0.000006298574,0.0009181684,0.0000417195,0.8221012,0.0001037295,0.00007733586,0.1739005],"study_design_scores_gemma":[0.006655918,0.002125165,0.009919671,0.00004726649,0.00006221065,0.00002964615,0.0002080178,0.0001588802,0.9696909,0.0003940334,0.01046946,0.0002388558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865426,0.008644435,0.00161425,0.0004099842,0.000480317,0.00184248,0.00003286331,0.00005313226,0.0003798784],"genre_scores_gemma":[0.9817142,0.01588534,0.0005918735,0.000404874,0.0002572436,0.0002299214,0.0001204889,0.00008807341,0.0007079978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1736616,"threshold_uncertainty_score":0.9972715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05049384806446507,"score_gpt":0.3478016085231401,"score_spread":0.297307760458675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}