{"id":"W1983129403","doi":"10.1074/jbc.m102876200","title":"1α,25-Dihydroxyvitamin D3-induced Monocyte Antimycobacterial Activity Is Regulated by Phosphatidylinositol 3-Kinase and Mediated by the NADPH-dependent Phagocyte Oxidase","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":239,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Vancouver Hospital and Health Sciences Centre","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council; National Institutes of Health; U.S. Public Health Service; Medical Research Council Canada; U.S. Department of Veterans Affairs","keywords":"Superoxide; Antimycobacterial; Superoxide dismutase; Wortmannin; Molecular biology; Phosphatidylinositol; NADPH oxidase; Monocyte; Phagocyte; Biology; Chemistry; Biochemistry; Reactive oxygen species; Mycobacterium tuberculosis; Kinase; Immunology; Enzyme; Phagocytosis; Medicine; Tuberculosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004250895,0.0002857715,0.0005325285,0.00003132244,0.0001505714,0.0000747065,0.0002196809,0.0003351533,0.000653989],"category_scores_gemma":[0.0003444182,0.0001682023,0.0002195085,0.0001756893,0.0001257121,0.0001367929,0.00005375579,0.0007497824,0.000006275792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009889333,"about_ca_system_score_gemma":0.00007423224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003205675,"about_ca_topic_score_gemma":3.499988e-7,"domain_scores_codex":[0.9983376,0.00009851411,0.0005707876,0.0003009239,0.0003765498,0.0003156515],"domain_scores_gemma":[0.9984913,0.0002459087,0.0005343955,0.0002477104,0.0001845636,0.0002960588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001138666,0.0005883084,0.0008841339,0.00002200399,0.000137091,0.0002851066,0.00006830205,2.706569e-7,0.9856687,5.283953e-7,0.009359559,0.001847394],"study_design_scores_gemma":[0.002747616,0.0007067889,0.002514753,0.00009452552,0.0001241468,0.002252344,0.0001124602,0.0001111344,0.9781515,0.00001094615,0.01298404,0.0001897669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962739,0.0007319082,0.00003398353,0.002071057,0.0001715463,0.0001655057,0.000120627,0.00002906238,0.0004024465],"genre_scores_gemma":[0.9978412,0.0005848033,0.00003633335,0.0006707584,0.0004892107,0.000005306594,0.00007436224,0.00001542357,0.0002825735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007517153,"threshold_uncertainty_score":0.716072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0243116727156788,"score_gpt":0.2711564344810002,"score_spread":0.2468447617653214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}