{"id":"W1983129403","doi":"10.1074/jbc.m102876200","title":"1α,25-Dihydroxyvitamin D3-induced Monocyte Antimycobacterial Activity Is Regulated by Phosphatidylinositol 3-Kinase and Mediated by the NADPH-dependent Phagocyte Oxidase","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":239,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Vancouver Hospital and Health Sciences Centre","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council; National Institutes of Health; U.S. Public Health Service; Medical Research Council Canada; U.S. Department of Veterans Affairs","keywords":"Superoxide; Antimycobacterial; Superoxide dismutase; Wortmannin; Molecular biology; Phosphatidylinositol; NADPH oxidase; Monocyte; Phagocyte; Biology; Chemistry; Biochemistry; Reactive oxygen species; Mycobacterium tuberculosis; Kinase; Immunology; Enzyme; Phagocytosis; Medicine; Tuberculosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168492,0.0001853355,0.0002297738,0.0001381382,0.0001169253,0.0002316606,0.00009569666,0.0002018694,0.0007265814],"category_scores_gemma":[0.0001004218,0.0001199204,0.000257766,0.0001258345,0.0001641413,0.00007128877,0.0001346251,0.0003032057,0.0002922812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003239945,"about_ca_system_score_gemma":0.0001966628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007361549,"about_ca_topic_score_gemma":0.001825603,"domain_scores_codex":[0.9998895,0.0000234849,0.000009225632,0.00002064965,0.00002373867,0.00003346368],"domain_scores_gemma":[0.9999226,0.00001541514,0.00002279073,0.00000784128,0.00001221881,0.00001902879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001589442,0.00001060128,0.0002407312,0.00002101459,0.000002201782,0.00004799634,0.000008078716,0.00001357833,0.9989513,0.00003015399,0.00001484752,0.0005005542],"study_design_scores_gemma":[0.00006167873,0.0005354488,0.02981406,0.000009870941,0.00002090467,0.0004466052,0.0000701825,0.0007457293,0.9649498,0.00009239386,0.00324609,0.000007183878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930702,0.003721162,0.00144491,0.0001021777,0.00003212793,0.00005142417,0.0005510706,0.00002933148,0.0009977211],"genre_scores_gemma":[0.99497,0.001546682,0.001576517,0.00006877445,0.00001014763,0.00004344496,0.0005138321,0.000006136602,0.001264351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007361549,"threshold_uncertainty_score":0.002430677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0243116727156788,"score_gpt":0.2711564344810002,"score_spread":0.2468447617653214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}