{"id":"W1983132670","doi":"10.1139/y07-029","title":"Insulin withdrawal induces apoptosis via a free radical-mediated mechanismThis paper is one of a selection of papers published in this Special Issue, entitled The Cellular and Molecular Basis of Cardiovascular Dysfunction, Dhalla 70th Birthday Tribute.","year":2007,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Insulin; Insulin resistance; Insulin receptor; Endocrinology; Apoptosis; Internal medicine; Protein kinase B; Oxidative stress; Reactive oxygen species; Diabetes mellitus; Oxidative phosphorylation; Biology; Medicine; Cell biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009876434,0.0001339537,0.0004202208,0.0003098013,0.00006690632,0.000004046454,0.0002218197,0.0002453283,0.007515439],"category_scores_gemma":[0.0002762225,0.0001133309,0.000115311,0.0003841526,0.0004633491,0.00002077009,0.00004320622,0.0003110942,5.734577e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003273423,"about_ca_system_score_gemma":0.0004356211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008480766,"about_ca_topic_score_gemma":0.0005193237,"domain_scores_codex":[0.9985042,0.0003384636,0.0004977317,0.0002396234,0.0001551809,0.0002648294],"domain_scores_gemma":[0.9988206,0.00007759072,0.0003203797,0.0001784191,0.0004188024,0.0001841887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004060037,0.00005567164,0.0003041835,0.00007327076,0.000691568,0.000005248336,0.0002622817,0.00008192161,0.9945861,0.00002483781,0.001839274,0.001669632],"study_design_scores_gemma":[0.001606358,0.0005127236,0.001162805,0.00001095071,0.0001279525,0.00001526441,0.00008004635,0.00001029844,0.9715202,0.0004248263,0.02443608,0.00009250719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944004,0.003356849,0.0004644135,0.001019701,0.0003285345,0.0002157676,0.00003712588,0.000001155842,0.0001760141],"genre_scores_gemma":[0.9975995,0.001308168,0.0002466583,0.0003071245,0.0004574299,0.000004888519,0.00002229214,0.00001264351,0.00004124297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02306592,"threshold_uncertainty_score":0.9933918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006534595704547443,"score_gpt":0.2331696049128984,"score_spread":0.226635009208351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}