{"id":"W1983163251","doi":"10.1038/onc.2009.361","title":"Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition","year":2009,"lang":"en","type":"article","venue":"Oncogene","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Biology; DNA methylation; Cancer research; DNA demethylation; Methyltransferase; Methylation; Molecular biology; Histone deacetylase inhibitor; Histone H3; Azacitidine; Epigenetics; Promoter; Histone deacetylase; Histone; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001893767,0.0001753544,0.0001940518,0.00004483266,0.00006493725,0.00001536689,0.000143762,0.0001620655,0.00005014097],"category_scores_gemma":[0.00008380312,0.0001674278,0.0001026563,0.0000990528,0.00006571199,0.000004950838,0.00005545794,0.00006025912,0.000007203373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001127714,"about_ca_system_score_gemma":0.00005204627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001088736,"about_ca_topic_score_gemma":0.000004921758,"domain_scores_codex":[0.9987029,0.00008324954,0.0003650091,0.0003772501,0.000225166,0.0002464471],"domain_scores_gemma":[0.9991645,0.00001456557,0.0001677032,0.000387917,0.0001506048,0.0001146803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008694223,0.0001338397,0.0004351736,0.0000108249,0.00001074586,0.000002106032,0.00001686897,0.00008695869,0.9860658,0.00002877797,0.0009215561,0.01220042],"study_design_scores_gemma":[0.0005091873,0.0007806823,0.001436356,0.00002647585,0.00001871243,0.000002306043,0.00001369192,0.0000482588,0.9852968,0.0004048705,0.01126478,0.0001978734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876347,0.005986543,0.004445089,0.0001551642,0.00008999479,0.0001948024,0.00007159416,0.00001370977,0.001408459],"genre_scores_gemma":[0.9951597,0.0009136643,0.002918715,0.0001528423,0.0001814264,0.00001143009,0.0003540709,0.00001999112,0.0002881376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01200255,"threshold_uncertainty_score":0.6827506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007135921307345053,"score_gpt":0.2551864071229822,"score_spread":0.2480504858156372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}