{"id":"W1983163251","doi":"10.1038/onc.2009.361","title":"Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition","year":2009,"lang":"en","type":"article","venue":"Oncogene","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Biology; DNA methylation; Cancer research; DNA demethylation; Methyltransferase; Methylation; Molecular biology; Histone deacetylase inhibitor; Histone H3; Azacitidine; Epigenetics; Promoter; Histone deacetylase; Histone; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001024427,0.000292836,0.0002529262,0.0001918035,0.0001046779,0.0002297057,0.0002310877,0.0001573734,0.0008643899],"category_scores_gemma":[0.00008708678,0.0001125147,0.0002162459,0.0001290264,0.0001688896,0.0001146527,0.0001375215,0.0005542675,0.000200396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003709767,"about_ca_system_score_gemma":0.0002098123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006398601,"about_ca_topic_score_gemma":0.001383832,"domain_scores_codex":[0.9998654,0.00001303719,0.00001275572,0.00002904373,0.00004092617,0.00003887022],"domain_scores_gemma":[0.9999387,0.00001358001,0.00001790797,0.00001041555,0.000005505376,0.00001393154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005023355,0.00002570099,0.0001111553,0.00001220132,0.000003810284,0.00002261687,0.000007078045,0.00006549928,0.9981841,0.0000859373,0.00002069391,0.001410868],"study_design_scores_gemma":[0.00001175151,0.0001674093,0.001398693,0.000001220723,0.000007197606,0.00004966163,0.000006199034,0.0006871057,0.9965485,0.00001998203,0.00110103,0.000001216459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966199,0.0007867009,0.001240294,0.00005696907,0.00002755294,0.00002358065,0.0001926919,0.00009277405,0.0009593534],"genre_scores_gemma":[0.9969131,0.0003549709,0.0008449453,0.00002330201,0.000006265122,0.00002193878,0.00028854,0.00001199651,0.00153484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008643899,"threshold_uncertainty_score":0.00289166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007135921307345053,"score_gpt":0.2551864071229822,"score_spread":0.2480504858156372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}