{"id":"W1983181509","doi":"10.1016/j.ijpharm.2006.11.045","title":"Human oral drugs absorption is correlated to their in vitro uptake by brush border membrane vesicles","year":2006,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Brush border; Vesicle; Enterocyte; Absorption (acoustics); Chemistry; Drug; Mannitol; Membrane; Biochemistry; Pharmacology; Small intestine; Biophysics; Chromatography; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005631773,0.0004226809,0.0006628389,0.0003984744,0.0002752022,0.0007348063,0.0002098439,0.00054675,0.004150258],"category_scores_gemma":[0.001285923,0.0004723366,0.0005777422,0.0003119668,0.0004173494,0.000725726,0.0003125279,0.0008249423,0.001414043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003706791,"about_ca_system_score_gemma":0.0002513787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001519468,"about_ca_topic_score_gemma":0.0007696289,"domain_scores_codex":[0.9994616,0.0002201674,0.00003339508,0.0000830296,0.00009049916,0.0001113313],"domain_scores_gemma":[0.9989905,0.0005154614,0.0001757721,0.0001006002,0.0001346367,0.00008300487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007946863,0.0002140637,0.006343176,0.0002994102,0.00018525,0.0002556184,0.0002848425,0.0004269817,0.9695745,0.0004232804,0.0003771294,0.01366897],"study_design_scores_gemma":[0.00007841027,0.002811047,0.05598234,0.00003112183,0.0001839356,0.001038547,0.0002314078,0.005139553,0.9306694,0.0002364443,0.003561856,0.00003585371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823681,0.009620844,0.00453147,0.0001922259,0.00005991263,0.00005671964,0.0005165264,0.0001317174,0.002522395],"genre_scores_gemma":[0.990353,0.003002211,0.001393998,0.00005813745,0.00003028776,0.0000289346,0.0008305776,0.00005629734,0.004246427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004150258,"threshold_uncertainty_score":0.01388407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871458197889965,"score_gpt":0.3408996812986083,"score_spread":0.3221850993197086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}