{"id":"W1983212020","doi":"10.1016/j.ejpb.2006.08.006","title":"Maintenance of vascular endothelial growth factor and potentially other therapeutic proteins bioactivity during a photo-initiated free radical cross-linking reaction forming biodegradable elastomers","year":2006,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Elastomer; Radical; Macromonomer; Bovine serum albumin; Radical polymerization; Polymerization; Polymer chemistry; Radical initiator; Materials science; Photochemistry; Organic chemistry; Polymer; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007351291,0.0002901786,0.0003116848,0.0001435515,0.0001887601,0.00007148948,0.0002536296,0.0000930466,0.00001406729],"category_scores_gemma":[0.00003813914,0.0002429281,0.0002223566,0.0001425153,0.0003405266,0.00003908934,0.0001517602,0.0002927471,7.100905e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003372542,"about_ca_system_score_gemma":0.00007480718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002106556,"about_ca_topic_score_gemma":0.000003740065,"domain_scores_codex":[0.9981515,0.0002334269,0.0006356428,0.0002965975,0.0003133712,0.0003694011],"domain_scores_gemma":[0.9987278,0.00002597901,0.0006236082,0.0001801699,0.0002748224,0.0001676163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006136227,0.0001392073,0.01114055,0.00014938,0.0003044942,0.00004349941,0.00005994597,0.00002238646,0.9829972,0.00002288575,0.00001320395,0.004493599],"study_design_scores_gemma":[0.004314881,0.0002772021,0.0113782,0.0001099893,0.0002127717,0.0002360631,0.00004536834,0.0002829333,0.9622861,0.00003137861,0.02052134,0.0003037858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900075,0.006208824,0.00291157,0.00006787547,0.0002736073,0.0002177129,0.0001237523,0.00001112895,0.0001780134],"genre_scores_gemma":[0.9917326,0.006320406,0.001115388,0.0001679071,0.000530948,0.000001821637,0.000006989875,0.00006422436,0.0000597358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02071114,"threshold_uncertainty_score":0.990632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02722932003110922,"score_gpt":0.2870834024803541,"score_spread":0.2598540824492448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}