{"id":"W1983212020","doi":"10.1016/j.ejpb.2006.08.006","title":"Maintenance of vascular endothelial growth factor and potentially other therapeutic proteins bioactivity during a photo-initiated free radical cross-linking reaction forming biodegradable elastomers","year":2006,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Elastomer; Radical; Macromonomer; Bovine serum albumin; Radical polymerization; Polymerization; Polymer chemistry; Radical initiator; Materials science; Photochemistry; Organic chemistry; Polymer; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004499504,0.0003495484,0.0001462385,0.0001349428,0.0001389752,0.0002293722,0.0002185063,0.0003876812,0.0008139361],"category_scores_gemma":[0.0003995266,0.0001846812,0.0002494027,0.0001112715,0.0002587092,0.0004422874,0.0001672914,0.0004161086,0.0001588695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001924255,"about_ca_system_score_gemma":0.0001158579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001693557,"about_ca_topic_score_gemma":0.0002953232,"domain_scores_codex":[0.9998344,0.00003111375,0.00001395453,0.00004043596,0.00003176459,0.00004819837],"domain_scores_gemma":[0.9996754,0.0001133788,0.0001119172,0.00003907157,0.00002476731,0.00003547705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007921889,0.00001608642,0.00005564684,0.00001850722,0.000004391505,0.00005024306,0.00002745808,0.0001213236,0.9987084,0.0000892499,0.00001240814,0.000817153],"study_design_scores_gemma":[0.00000544627,0.00006782496,0.0002325748,0.000001081287,0.000004234834,0.00003374619,0.000003548504,0.0002682974,0.9992004,0.000009741432,0.0001708062,0.000002257407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934843,0.0005709201,0.005027119,0.00004915805,0.00001765893,0.0000230841,0.00003734658,0.00006826098,0.0007222345],"genre_scores_gemma":[0.9972157,0.0001534802,0.00180954,0.00002081016,0.000005430535,0.00001239063,0.00002815282,0.00001618555,0.00073813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008139361,"threshold_uncertainty_score":0.002722859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02722932003110922,"score_gpt":0.2870834024803541,"score_spread":0.2598540824492448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}