{"id":"W1983239966","doi":"10.1038/sj.gt.3302005","title":"Herpes simplex virus type-1 infection upregulates cellular promoters and telomerase activity in both tumor and nontumor human cells","year":2003,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital; McMaster University; University of British Columbia","funders":"University of Pittsburgh; University of Pennsylvania","keywords":"Telomerase reverse transcriptase; Biology; Telomerase; Promoter; Herpes simplex virus; Virology; Viral vector; Gene expression; Viral replication; Carcinogenesis; Molecular biology; Gene; Virus; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004055025,0.000232771,0.0002039612,0.00009698388,0.0001338525,0.0000497623,0.00008661203,0.0001084858,0.00005273724],"category_scores_gemma":[0.00001166193,0.0002222287,0.00004252695,0.0001517114,0.00013426,0.00001079041,0.00004038432,0.0001093186,0.000003782798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002525864,"about_ca_system_score_gemma":0.00006667803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000201202,"about_ca_topic_score_gemma":0.0004906371,"domain_scores_codex":[0.9986123,0.0002684217,0.0001614287,0.0004723588,0.000128761,0.0003567657],"domain_scores_gemma":[0.9994441,0.0000123788,0.00006318432,0.0003270935,0.00003951368,0.0001137596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008162614,0.000158663,0.001635991,0.00001472563,0.00004482286,0.000009646492,0.00008951175,0.00002935164,0.9785767,0.000003658919,0.00004288023,0.0185778],"study_design_scores_gemma":[0.001480667,0.001937848,0.005552125,0.000006228387,0.000004539123,0.000009820922,0.00001191827,0.00003664639,0.9852782,0.0001272553,0.005302113,0.0002526278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971406,0.002186015,0.00003615516,0.00003286182,0.00005592085,0.0004644069,0.000009721499,0.00001716592,0.00005715094],"genre_scores_gemma":[0.997497,0.001910536,0.0001181846,0.0001527624,0.00007120252,0.00003192836,0.00001932695,0.00004534926,0.000153733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01832518,"threshold_uncertainty_score":0.9062224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01683701982396412,"score_gpt":0.2809796233337787,"score_spread":0.2641426035098146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}