{"id":"W1983265239","doi":"10.1371/journal.pgen.1003390","title":"Genetic and Genomic Architecture of the Evolution of Resistance to Antifungal Drug Combinations","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of Toronto; Natural Sciences and Engineering Research Council of Canada; Burroughs Wellcome Fund","keywords":"Biology; Antifungal drug; Drug resistance; Calcineurin; Genetics; Candida albicans; Transplantation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002097523,0.0002425707,0.0003016378,0.001155327,0.0002554975,0.0005397898,0.0004738846,0.0006349316,0.001163639],"category_scores_gemma":[0.0005083847,0.0003489895,0.000367344,0.0007577704,0.0004065712,0.0002627003,0.0005981384,0.0007997756,0.0002820066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005799759,"about_ca_system_score_gemma":0.0003173823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001316607,"about_ca_topic_score_gemma":0.001985016,"domain_scores_codex":[0.9996878,0.00005129008,0.00002204068,0.0001183796,0.00006440191,0.00005620353],"domain_scores_gemma":[0.9996203,0.0001004953,0.000113839,0.00004919165,0.00005966779,0.00005647439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003581605,0.0001005449,0.01785007,0.00007756254,0.00005629524,0.0004227447,0.0001949557,0.002199957,0.9645454,0.001676986,0.00009091879,0.0124264],"study_design_scores_gemma":[0.0001035709,0.001084971,0.8430544,0.00008594066,0.0002357352,0.002999792,0.0006559871,0.0226658,0.1140181,0.0032802,0.01169197,0.0001235688],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994877,0.0003782886,0.001842913,0.00007142291,0.000005655826,0.00002947612,0.0005764463,0.00005260818,0.002166071],"genre_scores_gemma":[0.9947121,0.0004065128,0.002537947,0.0001009398,0.00000800922,0.00004304173,0.001265367,0.0000426786,0.0008834205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001316607,"threshold_uncertainty_score":0.004208088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008324847861307197,"score_gpt":0.2214402525035587,"score_spread":0.2131154046422515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}