{"id":"W1983276692","doi":"10.1021/ol303416k","title":"Nahuoic Acid A Produced by a <i>Streptomyces</i> sp. Isolated From a Marine Sediment Is a Selective SAM-Competitive Inhibitor of the Histone Methyltransferase SETD8","year":2012,"lang":"en","type":"article","venue":"Organic Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto; University of British Columbia","funders":"Canadian Cancer Society Research Institute; GlaxoSmithKline; Pfizer","keywords":"Chemistry; Streptomyces; Epigenetics; Lysine; Methyltransferase; Polyketide; Histone; Biochemistry; Stereochemistry; Histone methyltransferase; Sediment; Enzyme; Methylation; Amino acid; Gene; Biology; Bacteria; Genetics; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007055922,0.0005295401,0.0002873944,0.0002887096,0.0001572549,0.0002020011,0.0001361686,0.0002354746,0.0005866544],"category_scores_gemma":[0.0001022826,0.000109934,0.0002326254,0.0002440112,0.0001402994,0.00009774158,0.0001710224,0.0003157429,0.0002454247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000113587,"about_ca_system_score_gemma":0.00019988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004286691,"about_ca_topic_score_gemma":0.0006485544,"domain_scores_codex":[0.9999051,0.00001622798,0.00001221653,0.00001791623,0.00002497484,0.00002355655],"domain_scores_gemma":[0.9999143,0.00001075436,0.00002314597,0.000005902062,0.000009185756,0.00003674895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001153593,0.00002058502,0.0002180752,0.00002821603,0.000005054665,0.00007131902,0.000004325187,0.00005774004,0.9978756,0.00002341441,0.0000156114,0.001564758],"study_design_scores_gemma":[0.00001382012,0.0004288639,0.001484961,0.000003736971,0.00001215761,0.0001445269,0.00001195519,0.0001834483,0.9967373,0.00001390115,0.0009616801,0.000003672266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894279,0.002822293,0.00421118,0.0000806406,0.00007528777,0.00008279396,0.0006012425,0.0001110256,0.002587722],"genre_scores_gemma":[0.994767,0.001040119,0.002904017,0.00003106344,0.0000172977,0.00001607009,0.0004886573,0.000009424708,0.0007263605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005866544,"threshold_uncertainty_score":0.001962543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005163766830401855,"score_gpt":0.2100194207089932,"score_spread":0.2048556538785914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}