{"id":"W1983286938","doi":"10.1016/j.febslet.2010.12.033","title":"Hypoxia-inducible factor independent down-regulation of thioredoxin-interacting protein in hypoxia","year":2010,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto","keywords":"TXNIP; Thioredoxin-Interacting Protein; Carbohydrate-responsive element-binding protein; Glycolysis; Hypoxia (environmental); Chemistry; Transcription factor; Carbohydrate metabolism; Hypoxia-inducible factors; Cell biology; Biochemistry; Thioredoxin; Metabolism; Biology; Oxygen; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009824769,0.0002071012,0.0001475571,0.0001309269,0.0001270243,0.0001816073,0.0001568897,0.0001752314,0.001119344],"category_scores_gemma":[0.0000782444,0.0000929058,0.000195735,0.00007707258,0.0001387561,0.0001113685,0.0001744079,0.0003995283,0.0002984324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001976309,"about_ca_system_score_gemma":0.0001169264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004058364,"about_ca_topic_score_gemma":0.0005025252,"domain_scores_codex":[0.9999374,0.00001230239,0.000004798696,0.00001047415,0.00001586583,0.00001923312],"domain_scores_gemma":[0.9999222,0.00001055324,0.00002032098,0.00001103913,0.00001301681,0.00002294118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006438629,0.00001234504,0.00008942289,0.00001707501,0.00000253185,0.00006629343,0.000003925945,0.00001401934,0.9988661,0.0000815186,0.00007455192,0.0007078553],"study_design_scores_gemma":[0.00002189904,0.0002031454,0.01402284,0.000004494791,0.00001515526,0.0005260422,0.00002024921,0.0008874592,0.9791812,0.00008457949,0.005029092,0.000003735126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883192,0.005281947,0.003198743,0.0003936786,0.0001293448,0.00002298685,0.0003098251,0.0001272039,0.002217135],"genre_scores_gemma":[0.991887,0.001206281,0.001239706,0.0001545886,0.00002923697,0.00002669632,0.0006806864,0.00001856801,0.004757287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001119344,"threshold_uncertainty_score":0.003744602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009747176141210543,"score_gpt":0.2395521445883766,"score_spread":0.2298049684471661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}