{"id":"W1983307326","doi":"10.1093/nar/gkh742","title":"Essential structural and functional determinants within the forkhead domain of FOXC1","year":2004,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; University of Alberta","keywords":"Transactivation; Biology; Forkhead Transcription Factors; Transcription factor; Genetics; Amino acid; DNA-binding domain; Transcription (linguistics); Protein structure; DNA; DNA-binding protein; Computational biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003290074,0.00007222144,0.0000699447,0.00005514567,0.0001433362,0.00002150566,0.0001157454,0.00009659477,0.00002444145],"category_scores_gemma":[0.00003936385,0.00005256779,0.00003607228,0.0001058384,0.0004361541,0.000006215,0.0000684548,0.0001165094,0.000003645804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000140657,"about_ca_system_score_gemma":0.00006497531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008746563,"about_ca_topic_score_gemma":0.0001488125,"domain_scores_codex":[0.9990918,0.00007854526,0.0001341084,0.0001922558,0.0003296677,0.0001736314],"domain_scores_gemma":[0.9995983,0.00000956742,0.00003574079,0.000214718,0.00009396095,0.00004776269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000169841,0.00001528527,0.007990296,0.00001903085,0.00002006495,0.000001116841,0.000150156,0.00004855171,0.9884764,0.001949594,0.000382688,0.0007769626],"study_design_scores_gemma":[0.002382137,0.0005964144,0.2724661,0.00003620412,0.00001122392,0.00007411346,0.0005114882,0.0001993665,0.7120624,0.007965523,0.003487781,0.0002071973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982707,0.000126749,0.0008053189,0.0002072957,0.00009917155,0.0001738175,0.00001072509,0.000007654216,0.0002986071],"genre_scores_gemma":[0.9988881,0.00000909647,0.0005970225,0.00001582286,0.0001252253,0.000008207314,0.00002218652,0.00001934425,0.0003150333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.276414,"threshold_uncertainty_score":0.2143652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02905274416816108,"score_gpt":0.3205836051845049,"score_spread":0.2915308610163438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}