{"id":"W1983348564","doi":"10.1074/jbc.m003497200","title":"Identification of a Novel Sequence Involved in Lysosomal Sorting of the Sphingolipid Activator Protein Prosaposin","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Sphingolipid; Activator (genetics); Cell biology; Identification (biology); Computational biology; Chemistry; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000733923,0.000370447,0.0002186849,0.0002083715,0.0001839632,0.0002969978,0.0001984262,0.000482977,0.0009233715],"category_scores_gemma":[0.0001789437,0.0001281995,0.000342593,0.0001716884,0.0001902661,0.0002023172,0.0001765536,0.0004957778,0.0009655139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002355925,"about_ca_system_score_gemma":0.0002510199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003813546,"about_ca_topic_score_gemma":0.0002843349,"domain_scores_codex":[0.9999322,0.000009686919,0.000007427218,0.00002016845,0.00001661515,0.00001395925],"domain_scores_gemma":[0.9997786,0.00004248405,0.00005904253,0.00001832674,0.00003362176,0.00006800318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007207206,0.000006647075,0.0001450235,0.00002156579,0.000001675094,0.0001912582,0.000008366978,0.00003187095,0.9988198,0.00005834442,0.00001011813,0.0006333943],"study_design_scores_gemma":[0.00003760739,0.0003690229,0.02076128,0.00002636605,0.00003636849,0.003070478,0.00007505903,0.002193861,0.9657849,0.0002042596,0.00742321,0.00001740889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901613,0.001033171,0.007086959,0.00008384376,0.00004231336,0.00005685301,0.0004608987,0.00004224288,0.001032421],"genre_scores_gemma":[0.9846438,0.0009225402,0.009779198,0.0001632158,0.00004044393,0.00004994787,0.002131896,0.00002374399,0.00224506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009233715,"threshold_uncertainty_score":0.003088951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05562569824101864,"score_gpt":0.3181422465591974,"score_spread":0.2625165483181788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}