{"id":"W1983364819","doi":"10.1002/gepi.20481","title":"Gene‐ or region‐based analysis of genome‐wide association studies","year":2009,"lang":"en","type":"article","venue":"Genetic Epidemiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Ontario Institute for Cancer Research; Institute for Clinical Evaluative Sciences; University of Toronto; SickKids Foundation; Hospital for Sick Children; Public Health Ontario","funders":"Natural Sciences and Engineering Research Council of Canada; Genome Canada; Mitacs; Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; Ontario Genomics Institute","keywords":"Univariate; Genotyping; False positive paradox; Genetic association; Genome-wide association study; Haplotype; Computational biology; Biology; Genome; Multiple comparisons problem; Single-nucleotide polymorphism; Genetics; Data mining; Genotype; Computer science; Gene; Statistics; Machine learning; Multivariate statistics; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0114996,0.0009846081,0.001996098,0.00596437,0.0005295287,0.001867656,0.001642673,0.0008689114,0.003526703],"category_scores_gemma":[0.03743742,0.0004795982,0.00238746,0.006911162,0.0006715991,0.0006117602,0.001286987,0.001450721,0.00138896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004504897,"about_ca_system_score_gemma":0.001418735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002132843,"about_ca_topic_score_gemma":0.001733832,"domain_scores_codex":[0.9898387,0.007184944,0.0004591503,0.001070185,0.001247375,0.0001997067],"domain_scores_gemma":[0.9782577,0.01760472,0.0009274362,0.002072925,0.0008981119,0.0002390402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00186659,0.0004519547,0.1303171,0.002575204,0.006896831,0.002586362,0.0007831274,0.06475733,0.04452861,0.05902149,0.01788349,0.6683319],"study_design_scores_gemma":[0.0005268516,0.001157215,0.2174028,0.0004559577,0.003658339,0.003170931,0.0005227749,0.4700329,0.03001136,0.1787009,0.09395401,0.0004059202],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.03724045,0.005189579,0.9456341,0.0008594671,0.0003165461,0.0004336564,0.004052345,0.003121098,0.003152851],"genre_scores_gemma":[0.299296,0.003486257,0.6877239,0.0004618863,0.0002631547,0.00117664,0.005480613,0.0004812893,0.001630222],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.0114996,"threshold_uncertainty_score":0.06081641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05588433739376503,"score_gpt":0.3420143503554338,"score_spread":0.2861300129616688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}