{"id":"W1983364819","doi":"10.1002/gepi.20481","title":"Gene‐ or region‐based analysis of genome‐wide association studies","year":2009,"lang":"en","type":"article","venue":"Genetic Epidemiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Ontario Institute for Cancer Research; Institute for Clinical Evaluative Sciences; University of Toronto; SickKids Foundation; Hospital for Sick Children; Public Health Ontario","funders":"Natural Sciences and Engineering Research Council of Canada; Genome Canada; Mitacs; Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; Ontario Genomics Institute","keywords":"Univariate; Genotyping; False positive paradox; Genetic association; Genome-wide association study; Haplotype; Computational biology; Biology; Genome; Multiple comparisons problem; Single-nucleotide polymorphism; Genetics; Data mining; Genotype; Computer science; Gene; Statistics; Machine learning; Multivariate statistics; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.002021996,0.000288535,0.001269559,0.0003305366,0.0001158012,0.000003440915,0.0003342701,0.0005380475,0.00004449645],"category_scores_gemma":[0.01809025,0.0002425283,0.0004927922,0.0007064037,0.0001336511,0.000002458515,0.00007637317,0.0001354528,0.00001095505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001162901,"about_ca_system_score_gemma":0.000152201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000284333,"about_ca_topic_score_gemma":0.0001217641,"domain_scores_codex":[0.9960777,0.001213043,0.001223181,0.00069007,0.0001309814,0.0006650063],"domain_scores_gemma":[0.9955084,0.002189958,0.001049043,0.0007277456,0.0003949069,0.0001299407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001246274,0.0001034553,0.9341289,0.00001207715,0.002757774,0.000004639494,0.00007242836,0.04244355,0.004744238,0.00006348432,0.01251772,0.003027049],"study_design_scores_gemma":[0.0005139614,0.0007991646,0.9862114,0.000005266104,0.001049216,0.000004718773,0.0000792891,0.001826015,0.0008890242,0.001784966,0.006550027,0.0002869139],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.922123,0.006769945,0.06308784,0.007101561,0.0002428067,0.0003009257,0.00004182976,0.00002885375,0.0003033082],"genre_scores_gemma":[0.9345441,0.002990179,0.0486711,0.0120064,0.0002336656,0.0000396398,0.0003174834,0.0000193193,0.001178074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05208248,"threshold_uncertainty_score":0.9901808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05588433739376503,"score_gpt":0.3420143503554338,"score_spread":0.2861300129616688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}