{"id":"W1983368955","doi":"10.1016/j.molimm.2004.09.007","title":"Methylation protects cytidines from AID-mediated deamination","year":2004,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Somatic hypermutation; Activation-induced (cytidine) deaminase; Cytidine deaminase; Biology; Genetics; Gene; CpG site; Methylation; DNA methylation; Antibody; Gene expression; B cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001972575,0.0003831907,0.0004839429,0.0003153047,0.0002684197,0.00002282669,0.000453026,0.0009133626,0.0005299465],"category_scores_gemma":[0.0002929371,0.0003716048,0.0001655517,0.0003596276,0.0004482009,0.0001529882,0.0001906998,0.0006366579,0.003358383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001652356,"about_ca_system_score_gemma":0.0001394671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001107905,"about_ca_topic_score_gemma":0.00007075592,"domain_scores_codex":[0.9976735,0.0004514991,0.0005138681,0.0006353465,0.00006348835,0.0006622998],"domain_scores_gemma":[0.9987891,0.0001481351,0.0002595403,0.0006152097,0.000162756,0.00002520443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002002338,0.0002336669,0.00009231552,0.000006290186,0.0004691704,0.00005827539,0.0003409976,0.00006311134,0.9906756,0.003113205,0.00006534557,0.004681765],"study_design_scores_gemma":[0.004457896,0.0004202584,0.001509739,0.00002685938,0.00006765377,0.00009610481,0.0001337672,0.00000521921,0.9671533,0.006030259,0.0197138,0.0003851585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725053,0.01127495,0.01187896,0.001175634,0.001302313,0.0005858455,0.00003558891,0.0003544504,0.0008869364],"genre_scores_gemma":[0.9969117,0.0001527566,0.0005722585,0.0003701731,0.00003343611,0.0001356445,0.001234777,0.00005140113,0.0005378193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02440641,"threshold_uncertainty_score":0.9998736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007153386897104379,"score_gpt":0.2119230417942111,"score_spread":0.2047696548971068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}