{"id":"W1983381811","doi":"10.1093/nar/gkh235","title":"Inhibitors of protein synthesis identified by a high throughput multiplexed translation screen","year":2004,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; Hereditary Disease Foundation","keywords":"Biology; Translation (biology); Eukaryotic translation; EIF4E; Internal ribosome entry site; Protein biosynthesis; Initiation factor; EIF4EBP1; Eukaryotic initiation factor; EIF4A1; Untranslated region; Computational biology; Cell biology; Biochemistry; Messenger RNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001142521,0.0001696837,0.0002211512,0.000121018,0.0001748176,0.00004267617,0.0004104131,0.000312025,0.0001108633],"category_scores_gemma":[0.0003959119,0.0001600911,0.0001229757,0.0002830787,0.000232447,0.00001421258,0.000112649,0.0001848592,0.00004808637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000365401,"about_ca_system_score_gemma":0.000120632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005365809,"about_ca_topic_score_gemma":0.00004189291,"domain_scores_codex":[0.997761,0.0003056995,0.0003455285,0.000479757,0.0006726258,0.000435421],"domain_scores_gemma":[0.9990092,0.00005071739,0.00008592322,0.0005278775,0.0002155143,0.0001107934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002419476,0.0001227034,0.00005635249,0.00004524141,0.00004691966,0.000002334318,0.00009859787,0.00001063494,0.9798235,0.0003417086,0.0003750787,0.01883496],"study_design_scores_gemma":[0.0006842088,0.0003135653,0.0001860125,0.00009408886,0.000008662513,0.00000200263,0.0001316909,0.000007401492,0.993442,0.001435971,0.003526184,0.0001681841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941019,0.0006284915,0.002720978,0.0005790308,0.00004806007,0.0009120795,0.00007722828,0.00002245535,0.0009097111],"genre_scores_gemma":[0.9921426,0.00009432176,0.00689389,0.00001753914,0.0001348137,0.0001782893,0.00005774934,0.00004777213,0.0004329856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01866677,"threshold_uncertainty_score":0.6528326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03722987701939062,"score_gpt":0.3079155582397367,"score_spread":0.2706856812203461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}