{"id":"W1983381811","doi":"10.1093/nar/gkh235","title":"Inhibitors of protein synthesis identified by a high throughput multiplexed translation screen","year":2004,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; Hereditary Disease Foundation","keywords":"Biology; Translation (biology); Eukaryotic translation; EIF4E; Internal ribosome entry site; Protein biosynthesis; Initiation factor; EIF4EBP1; Eukaryotic initiation factor; EIF4A1; Untranslated region; Computational biology; Cell biology; Biochemistry; Messenger RNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005978639,0.001104132,0.001677456,0.001172653,0.0003214225,0.0007204648,0.0004465903,0.0006273375,0.001577304],"category_scores_gemma":[0.0005018323,0.0003650714,0.0004626058,0.0007535797,0.0002280953,0.0002939269,0.0003529963,0.0007129473,0.0006569786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006271319,"about_ca_system_score_gemma":0.0004710706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005930414,"about_ca_topic_score_gemma":0.002068873,"domain_scores_codex":[0.9994183,0.00008758719,0.00004885447,0.0001011909,0.0002653904,0.00007870765],"domain_scores_gemma":[0.9995793,0.0001194375,0.00009950669,0.00004145331,0.0001047782,0.00005557778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002262283,0.00027469,0.0007596139,0.0001292695,0.00005073995,0.0000937798,0.00001564437,0.0009371847,0.9866732,0.00009308781,0.0002421515,0.01050449],"study_design_scores_gemma":[0.000119481,0.002026183,0.003799249,0.00001072531,0.0002194128,0.0004258294,0.00001186372,0.003599388,0.9859707,0.00005221236,0.003736737,0.00002816879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9349296,0.01231239,0.03978146,0.0004061504,0.0001272431,0.001650488,0.004242186,0.001046835,0.005503657],"genre_scores_gemma":[0.9303454,0.009074069,0.04180095,0.0003648606,0.0000916958,0.001329275,0.006018802,0.0001128686,0.01086206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001677456,"threshold_uncertainty_score":0.00527668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03722987701939062,"score_gpt":0.3079155582397367,"score_spread":0.2706856812203461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}