{"id":"W1983382084","doi":"10.1007/s40265-014-0212-x","title":"Teriflunomide and Its Mechanism of Action in Multiple Sclerosis","year":2014,"lang":"en","type":"review","venue":"Drugs","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":352,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Novartis Pharma; EMD Serono; Sanofi; Bayer HealthCare; Genentech; Else Kröner-Fresenius-Stiftung; Fresenius Medical Care North America; Deutsche Forschungsgemeinschaft; GlaxoSmithKline; Biogen; Teva Pharmaceutical Industries; Eli Lilly and Company","keywords":"Teriflunomide; Multiple sclerosis; Medicine; Immune system; Mechanism of action; Adverse effect; Immunology; Pharmacology; Pyrimidine metabolism; Disease; Internal medicine; Fingolimod; Enzyme; In vitro; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003720968,0.0001729002,0.001277509,0.0002910055,0.00002541197,0.000007417574,0.00008250619,0.0002276425,0.00006768457],"category_scores_gemma":[0.0001285573,0.0001406684,0.0001529297,0.0001634316,0.00003178233,0.00005322524,0.00007001305,0.0003042725,0.00006206544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005373102,"about_ca_system_score_gemma":0.0001566166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004513912,"about_ca_topic_score_gemma":0.000005510832,"domain_scores_codex":[0.9988462,0.00009625863,0.000488795,0.0002163416,0.0001760474,0.0001763265],"domain_scores_gemma":[0.9994121,0.00008877497,0.0001844848,0.000222155,0.00003966591,0.00005277734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001648569,0.0000348441,0.00001117397,0.02289945,0.00003394823,0.00000212498,0.0001080469,3.354076e-8,0.0001596636,0.0001947697,0.00008354816,0.9764559],"study_design_scores_gemma":[0.0009008455,0.00008774276,0.0001441646,0.01553587,0.0001521825,0.000009314103,0.00008911939,0.0001090129,0.0002639367,0.00002444113,0.9825254,0.0001579544],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002239405,0.9960611,0.000009516841,0.00002430402,0.00005497127,0.0007067184,0.000007980676,0.00001604436,0.0008799849],"genre_scores_gemma":[0.005293306,0.9939184,0.00002484342,0.00001867995,0.0000373373,0.00007410877,0.0000422073,0.00003254889,0.0005585694],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9824418,"threshold_uncertainty_score":0.573629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1187807072790366,"score_gpt":0.3515273827265237,"score_spread":0.2327466754474871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}