{"id":"W1983382084","doi":"10.1007/s40265-014-0212-x","title":"Teriflunomide and Its Mechanism of Action in Multiple Sclerosis","year":2014,"lang":"en","type":"review","venue":"Drugs","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":352,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Novartis Pharma; EMD Serono; Sanofi; Bayer HealthCare; Genentech; Else Kröner-Fresenius-Stiftung; Fresenius Medical Care North America; Deutsche Forschungsgemeinschaft; GlaxoSmithKline; Biogen; Teva Pharmaceutical Industries; Eli Lilly and Company","keywords":"Teriflunomide; Multiple sclerosis; Medicine; Immune system; Mechanism of action; Adverse effect; Immunology; Pharmacology; Pyrimidine metabolism; Disease; Internal medicine; Fingolimod; Enzyme; In vitro; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004187933,0.0008374311,0.001121272,0.002624802,0.0003274288,0.0007580583,0.0007187459,0.0009884514,0.003553453],"category_scores_gemma":[0.0004222623,0.0002823596,0.0004196811,0.002240254,0.0004098798,0.001174266,0.0005415611,0.00145811,0.002483766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005378905,"about_ca_system_score_gemma":0.0007901761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009225475,"about_ca_topic_score_gemma":0.001481755,"domain_scores_codex":[0.999863,0.00002030016,0.00002204095,0.0000258332,0.00005539605,0.00001335539],"domain_scores_gemma":[0.9998556,0.00006280358,0.00002727182,0.000005340463,0.00003375698,0.00001514747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008025089,0.0000699415,0.0001254133,0.01538725,0.00007128554,0.0002092894,0.00005902006,0.000318259,0.003412054,0.003455102,0.01468514,0.962127],"study_design_scores_gemma":[0.0000218338,0.0001140315,0.000755415,0.00273716,0.00009267316,0.001709398,0.00004477426,0.00007276372,0.0008666796,0.001589603,0.9919802,0.00001546559],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001467525,0.9982736,0.0001120419,0.000118342,0.0001232387,0.000006851555,0.00001521076,0.000007848921,0.001196119],"genre_scores_gemma":[0.0006323265,0.9982854,0.0002004328,0.00009907733,0.0000755498,0.000007775517,0.0000206246,0.000001286471,0.000677668],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003553453,"threshold_uncertainty_score":0.01188749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1187807072790366,"score_gpt":0.3515273827265237,"score_spread":0.2327466754474871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}