{"id":"W1983394665","doi":"10.1016/j.bmc.2005.03.047","title":"Design and synthesis of alkyl 7,7-dihalo-3-methyl-5-(nitrophenyl)-2-azabicyclo[4.1.0]hept-3-ene-4-carboxylates with calcium channel antagonist activity","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Animal Welfare Institute","keywords":"Chemistry; Ene reaction; Antagonist; Alkyl; Bicyclic molecule; Stereochemistry; Calcium channel; Chemical synthesis; Calcium; Lactam; Medicinal chemistry; Organic chemistry; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000256749,0.0005291884,0.000534635,0.0002693792,0.0002061813,0.0002191644,0.0006704559,0.0003252736,0.002451622],"category_scores_gemma":[0.0001870893,0.0003078217,0.0002562756,0.0002614756,0.0001934831,0.0002397714,0.0002993149,0.0004444382,0.001057933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003786415,"about_ca_system_score_gemma":0.0006829733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005831373,"about_ca_topic_score_gemma":0.00155209,"domain_scores_codex":[0.9998603,0.00002468279,0.00001366576,0.00002227558,0.00002773124,0.00005128421],"domain_scores_gemma":[0.9999167,0.000008035026,0.00002033549,0.000006513878,0.00001851564,0.00002991978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003680126,0.0001022934,0.0001060623,0.0002077436,0.00002008038,0.0001529271,0.00004869704,0.0009457049,0.985797,0.001045639,0.0002498069,0.01095595],"study_design_scores_gemma":[0.0003277629,0.001627157,0.000989798,0.00001611419,0.00005752229,0.0003057689,0.00002369303,0.001472307,0.9824463,0.0001985362,0.01251206,0.00002290319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9299781,0.007485714,0.04433136,0.0005295306,0.0002445809,0.0009447598,0.001423032,0.0004434185,0.01461952],"genre_scores_gemma":[0.9528235,0.007380954,0.02612604,0.0002364642,0.00006981782,0.0005019291,0.001614594,0.0000783363,0.01116845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002451622,"threshold_uncertainty_score":0.00820154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01272557287372315,"score_gpt":0.2264597173557121,"score_spread":0.213734144481989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}