{"id":"W1983394665","doi":"10.1016/j.bmc.2005.03.047","title":"Design and synthesis of alkyl 7,7-dihalo-3-methyl-5-(nitrophenyl)-2-azabicyclo[4.1.0]hept-3-ene-4-carboxylates with calcium channel antagonist activity","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Animal Welfare Institute","keywords":"Chemistry; Ene reaction; Antagonist; Alkyl; Bicyclic molecule; Stereochemistry; Calcium channel; Chemical synthesis; Calcium; Lactam; Medicinal chemistry; Organic chemistry; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003352634,0.0004629796,0.0005612615,0.0000548911,0.0001656071,0.00003507105,0.0003009483,0.00031317,0.00006706417],"category_scores_gemma":[0.0001654398,0.0003631233,0.0001082595,0.0001949316,0.0004821113,0.00002066051,0.0001362636,0.0002177827,0.000002155246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003922505,"about_ca_system_score_gemma":0.0002023589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007925938,"about_ca_topic_score_gemma":0.000007815041,"domain_scores_codex":[0.9981029,0.00007725041,0.0003501933,0.0006434201,0.0003457618,0.0004804751],"domain_scores_gemma":[0.9987342,0.0001306517,0.0002760412,0.0004985059,0.0001305738,0.0002300336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004927645,0.0002546049,0.0003063582,0.0002148606,0.0001739283,0.000008432127,0.0000727822,0.00001362514,0.9908997,0.000004772572,0.000432283,0.007125869],"study_design_scores_gemma":[0.0007606045,0.0002546611,0.0009113197,0.0001393095,0.0001738257,0.0001180968,0.0002969569,0.0001976458,0.9932401,0.00001929432,0.003437937,0.0004502471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908036,0.003304928,0.003486647,0.0008635772,0.00006940921,0.0002088067,0.00004860792,0.00003706792,0.001177349],"genre_scores_gemma":[0.9963494,0.0005814715,0.001363498,0.0001302301,0.0009289745,0.00003669362,0.00002273948,0.00006608704,0.0005209022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006675622,"threshold_uncertainty_score":0.9998821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01272557287372315,"score_gpt":0.2264597173557121,"score_spread":0.213734144481989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}