{"id":"W1983416562","doi":"10.1021/bi7024832","title":"Kinetic and Mechanistic Analysis of <i>Trypanosoma cruzi</i> Trans-Sialidase Reveals a Classical Ping-Pong Mechanism with Acid/Base Catalysis","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Anomer; Azide; Stereochemistry; Sialic acid; Active site; Biochemistry; Catalysis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00001533996,0.0002514677,0.0006688305,0.000258822,0.0001542966,0.00002077272,0.0001666673,0.0001708328,0.0002097267],"category_scores_gemma":[0.0002153559,0.000209527,0.0002281297,0.001334128,0.0003721643,0.00004772629,0.00005290624,0.000226497,0.000005067674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007407549,"about_ca_system_score_gemma":0.0002209013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004958876,"about_ca_topic_score_gemma":0.00001092716,"domain_scores_codex":[0.9980673,0.00003522437,0.0004141219,0.0005439795,0.0005505218,0.0003888321],"domain_scores_gemma":[0.9982792,0.00008851055,0.0001361879,0.0007627837,0.0002324616,0.0005008982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002141209,0.0002876926,0.0005257265,0.0002084456,0.0008688064,0.0001459137,0.0000960964,0.000001185276,0.9968008,0.0003388776,0.0003277698,0.0001845049],"study_design_scores_gemma":[0.001427011,0.0003491262,0.04017191,0.0001022864,0.002490967,0.0004563416,0.0001468524,0.00057014,0.9537696,0.00009537719,0.0001544922,0.0002659443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917361,0.0004044145,0.005505944,0.0009272576,0.00001017395,0.0002755615,0.0002201046,0.00006023757,0.000860185],"genre_scores_gemma":[0.9960424,0.0001626141,0.002249213,0.0001390491,0.00007263474,0.00006671681,0.0002953408,0.00002793269,0.0009440529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04303131,"threshold_uncertainty_score":0.8544262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02069025289157121,"score_gpt":0.2636417726487801,"score_spread":0.2429515197572089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}