{"id":"W1983486698","doi":"10.1016/j.biomaterials.2013.12.043","title":"Facilitated brain delivery of poly (ethylene glycol)–poly (lactic acid) nanoparticles by microbubble-enhanced unfocused ultrasound","year":2014,"lang":"en","type":"article","venue":"Biomaterials","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"National Key Research and Development Program of China; Fudan University; Science and Technology Commission of Shanghai Municipality; Shanghai Municipal Education Commission; National Natural Science Foundation of China; National Major Science and Technology Projects of China; Ministry of Higher Education and Scientific Research","keywords":"Ethylene glycol; Materials science; Nanoparticle; Sonication; Extravasation; Transcytosis; Blood–brain barrier; Drug delivery; Microbubbles; Ultrasound; Biophysics; Nanotechnology; Biomedical engineering; Chemistry; Medicine; Pathology; Central nervous system; Biochemistry; Endocytosis; Organic chemistry; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382203,0.0004017837,0.0002565063,0.0002060037,0.0001208038,0.0003112529,0.0002452967,0.0003754951,0.0005093793],"category_scores_gemma":[0.0001435234,0.0001565062,0.0002011934,0.0001071867,0.0001724816,0.0003695533,0.0002181476,0.0003567172,0.0002378409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003332597,"about_ca_system_score_gemma":0.0003340556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001181474,"about_ca_topic_score_gemma":0.001374347,"domain_scores_codex":[0.99992,0.0000118372,0.00000422526,0.00001554995,0.00001467944,0.00003375732],"domain_scores_gemma":[0.999959,0.000009587102,0.00001201801,0.000002946033,0.000007797269,0.000008742853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001011039,0.00001916593,0.00001675773,0.00004165558,0.000003841137,0.00006355655,0.0000155285,0.0001968728,0.9967986,0.0001639023,0.00005291705,0.002526136],"study_design_scores_gemma":[0.00001564171,0.0001448218,0.0002611802,0.000002995325,0.00001032329,0.00006875169,0.000007137052,0.001452171,0.9970836,0.0000363212,0.0009116179,0.000005304646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777418,0.004055893,0.01491604,0.0001958354,0.00007044047,0.00007662841,0.00008667847,0.000189921,0.002666768],"genre_scores_gemma":[0.9885688,0.001354886,0.006974323,0.00006578758,0.00002346409,0.00005034852,0.0000607778,0.00002790309,0.00287383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001181474,"threshold_uncertainty_score":0.002418041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007049802766550407,"score_gpt":0.2010857502412889,"score_spread":0.1940359474747385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}