{"id":"W1983490533","doi":"10.1097/01.mpa.0000335332.18675.0a","title":"GLYCOGEN SYNTHASE KINASE-3 (GSK3) ACTIVITY PLAYS CRUCIAL ROLE IN HUMAN PANCREATIC CANCER CELL PROLIFERATION AND SURVIVAL","year":2008,"lang":"en","type":"article","venue":"Pancreas","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"GSK-3; Cell growth; Glycogen synthase; Apoptosis; Hyperphosphorylation; Cell cycle; GSK3B; Biology; Kinase; Cancer research; Programmed cell death; Pancreatic cancer; Cell biology; Phosphorylation; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000148166,0.0003195702,0.0001965493,0.0003615263,0.0001563833,0.0003576819,0.00007736978,0.0001736559,0.001536544],"category_scores_gemma":[0.0001367167,0.00007753907,0.000346129,0.0003695343,0.0001961112,0.0001617843,0.0001865618,0.0003157555,0.0003993701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002660633,"about_ca_system_score_gemma":0.0003784905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000497602,"about_ca_topic_score_gemma":0.0005861862,"domain_scores_codex":[0.9999336,0.00001240143,0.000009020047,0.00001491585,0.00001498342,0.00001502234],"domain_scores_gemma":[0.9999226,0.00001123792,0.00003142707,0.000007168426,0.00001102658,0.00001639518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001582175,0.00009683318,0.01659899,0.0006727002,0.00006423225,0.0009089338,0.000108239,0.000383925,0.95494,0.0003954778,0.0007366012,0.02351195],"study_design_scores_gemma":[0.0001053427,0.001145166,0.1893939,0.0001607203,0.0002161244,0.004445945,0.0003261624,0.001156569,0.7829747,0.001191674,0.01885312,0.00003050196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9509243,0.03840136,0.003386226,0.0004132943,0.00009008785,0.0000466941,0.00142946,0.0002176342,0.005091003],"genre_scores_gemma":[0.986692,0.009761172,0.001165067,0.00006001431,0.00002234026,0.0000338207,0.0008185246,0.00001381567,0.00143318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001536544,"threshold_uncertainty_score":0.005140245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01419059176391042,"score_gpt":0.2485363118526851,"score_spread":0.2343457200887747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}