{"id":"W1983501707","doi":"10.1074/jbc.m500078200","title":"The Glucagon-like Peptide-2 Receptor C Terminus Modulates β-Arrestin-2 Association but Is Dispensable for Ligand-induced Desensitization, Endocytosis, and G-protein-dependent Effector Activation","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"","keywords":"G protein-coupled receptor; Internalization; Homologous desensitization; Cell biology; Receptor; Biology; Arrestin; Enzyme-linked receptor; G protein-coupled receptor kinase; G protein; 5-HT5A receptor; Endocytosis; Signal transduction; Glucagon-like peptide 1 receptor; Agonist; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001398814,0.0003161109,0.0002481901,0.0001106065,0.0001600747,0.0003498111,0.0002296978,0.0002475902,0.000781254],"category_scores_gemma":[0.0001278256,0.000172296,0.0003310617,0.00009488819,0.000239191,0.0002481016,0.0001817471,0.0006510762,0.0003968539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003715542,"about_ca_system_score_gemma":0.0002391422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004574143,"about_ca_topic_score_gemma":0.000632336,"domain_scores_codex":[0.9998592,0.00002663664,0.00001727518,0.00002868493,0.00003373979,0.00003439764],"domain_scores_gemma":[0.9998703,0.00002660928,0.00004232195,0.00001666768,0.0000125302,0.00003154701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006960669,0.00001034753,0.00004546957,0.00001003247,0.000002312046,0.00002659554,0.000003913097,0.00002830403,0.9995816,0.00004921767,0.000009862936,0.0001628503],"study_design_scores_gemma":[0.00003197082,0.0002010408,0.004572894,0.000007623565,0.00001631235,0.0003929711,0.0000282972,0.001530225,0.9914642,0.00003866149,0.001707155,0.000008682041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975179,0.0005041679,0.001024976,0.00004883148,0.00001578079,0.00001340777,0.0001739093,0.00002839972,0.0006725762],"genre_scores_gemma":[0.9970351,0.0003727675,0.001097812,0.00005638853,0.000006763318,0.000023179,0.0004231581,0.00002281577,0.0009618652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000781254,"threshold_uncertainty_score":0.002695858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426292693643259,"score_gpt":0.2408464863624607,"score_spread":0.2265835594260281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}