{"id":"W1983501707","doi":"10.1074/jbc.m500078200","title":"The Glucagon-like Peptide-2 Receptor C Terminus Modulates β-Arrestin-2 Association but Is Dispensable for Ligand-induced Desensitization, Endocytosis, and G-protein-dependent Effector Activation","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"","keywords":"G protein-coupled receptor; Internalization; Homologous desensitization; Cell biology; Receptor; Biology; Arrestin; Enzyme-linked receptor; G protein-coupled receptor kinase; G protein; 5-HT5A receptor; Endocytosis; Signal transduction; Glucagon-like peptide 1 receptor; Agonist; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005794145,0.0001715039,0.0002140018,0.00001304657,0.0002261364,0.0000893482,0.0001542723,0.0002961559,0.00002528737],"category_scores_gemma":[0.0008189328,0.0001114873,0.0001385639,0.000043744,0.00003055084,0.00001436501,0.00005401073,0.0001613293,0.000002034899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008769044,"about_ca_system_score_gemma":0.0000535195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000316937,"about_ca_topic_score_gemma":9.287279e-7,"domain_scores_codex":[0.9988807,0.00005556596,0.0004030081,0.0002322861,0.0001820028,0.0002464437],"domain_scores_gemma":[0.99878,0.0001538345,0.0005249587,0.0001282359,0.0003119497,0.0001010005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000204595,0.00003757174,0.0005254367,0.00001639747,0.00007341737,7.176241e-7,0.00001678386,0.000022883,0.9949633,0.00000323232,0.0009278236,0.003207812],"study_design_scores_gemma":[0.0006527545,0.0002736331,0.0002132336,0.00004116171,0.00002062113,0.00002731768,0.00006599674,0.0001614399,0.9900047,0.0000877218,0.008301786,0.0001496641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975055,0.0003203145,0.001197507,0.0005807032,0.0001231076,0.0002100625,0.00001806769,0.0000074063,0.00003726704],"genre_scores_gemma":[0.9965892,0.0002980541,0.00118098,0.0001446879,0.0009806515,0.0000181144,0.00004175539,0.00001471922,0.0007318171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007373963,"threshold_uncertainty_score":0.454632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426292693643259,"score_gpt":0.2408464863624607,"score_spread":0.2265835594260281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}