{"id":"W1983507733","doi":"10.1016/j.coph.2010.07.002","title":"Therapeutic applications of ribozymes and riboswitches","year":2010,"lang":"en","type":"review","venue":"Current Opinion in Pharmacology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Ribozyme; Riboswitch; Computational biology; RNA; Aptamer; Ligase ribozyme; Gene knockdown; Biology; Non-coding RNA; Bioinformatics; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008045327,0.001101119,0.001801573,0.001014105,0.000213278,0.0008852982,0.001137302,0.001373661,0.00280312],"category_scores_gemma":[0.0004357128,0.000270114,0.0004914677,0.001047783,0.0007581262,0.001186635,0.0005320827,0.00233196,0.00208238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006080079,"about_ca_system_score_gemma":0.0005144218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003007603,"about_ca_topic_score_gemma":0.0006589743,"domain_scores_codex":[0.9998079,0.00003244393,0.00001631956,0.0000442176,0.00007342734,0.00002571218],"domain_scores_gemma":[0.9998042,0.0001103396,0.000028095,0.000008351886,0.00003020395,0.00001887667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001631369,0.0001383561,0.0001297012,0.006116509,0.00007297437,0.0003164507,0.0000384779,0.0007168536,0.01625205,0.009844704,0.01892773,0.947283],"study_design_scores_gemma":[0.00009971725,0.0002808134,0.0007157717,0.001156538,0.0001181797,0.002005826,0.00004610349,0.0004368197,0.006248927,0.006422971,0.9824275,0.00004073285],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004068985,0.9954657,0.001241453,0.0004290252,0.0004692518,0.000009584529,0.00001582834,0.000021941,0.00194032],"genre_scores_gemma":[0.002867236,0.9932326,0.001017811,0.0005351563,0.0005336172,0.00001933604,0.00005911487,0.000004683412,0.001730516],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00280312,"threshold_uncertainty_score":0.00937736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06770039026874743,"score_gpt":0.4127241323215469,"score_spread":0.3450237420527995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}