{"id":"W1983523083","doi":"10.1371/journal.pone.0117215","title":"Target Modulation by a Kinase Inhibitor Engineered to Induce a Tandem Blockade of the Epidermal Growth Factor Receptor (EGFR) and c-Src: The Concept of Type III Combi-Targeting","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Regional Health Centre; Royal Victoria Hospital","funders":"Canadian Institutes of Health Research; Servier; McGill University Health Centre; McGill University","keywords":"Proto-oncogene tyrosine-protein kinase Src; Dasatinib; Kinase; Cancer research; Tyrosine kinase; Cell biology; Chemistry; Phosphorylation; EGFR inhibitors; SH3 domain; Tyrosine-kinase inhibitor; Epidermal growth factor receptor; Biology; Signal transduction; Biochemistry; Receptor; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001439176,0.0001292497,0.0002517494,0.00001872567,0.00007379219,0.00001241409,0.0001995258,0.00009374468,0.0001020274],"category_scores_gemma":[0.0005345955,0.00008965554,0.00004025999,0.0001787633,0.00008324547,0.00004917878,0.0000915439,0.0001511324,0.000003491771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003808633,"about_ca_system_score_gemma":0.00005158013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000667348,"about_ca_topic_score_gemma":0.000001513872,"domain_scores_codex":[0.9990005,0.00003937279,0.0003280149,0.0001818642,0.000291188,0.0001590012],"domain_scores_gemma":[0.9990459,0.0001595236,0.0001942498,0.0002784764,0.0002220755,0.00009977686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002298124,0.0003570353,0.003316048,0.00003936216,0.00006354997,5.527924e-8,0.001242016,0.00002108515,0.9929258,0.0001365051,0.001764629,0.0001109236],"study_design_scores_gemma":[0.0004025727,0.00002896507,0.0006635318,0.00009577828,0.00004037518,2.590001e-7,0.000340774,0.001158845,0.9965338,0.0001057037,0.0005187542,0.000110643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974772,0.000284449,0.00006899227,0.001547257,0.00002307177,0.0002407389,0.0001465408,0.00002482421,0.0001869749],"genre_scores_gemma":[0.9987311,0.000007943034,0.0008255395,0.00005063212,0.0001213382,0.00003550396,0.00002712369,0.00002034597,0.0001805068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003607989,"threshold_uncertainty_score":0.3656047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03186594421063559,"score_gpt":0.2232635314270348,"score_spread":0.1913975872163992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}