{"id":"W1983523083","doi":"10.1371/journal.pone.0117215","title":"Target Modulation by a Kinase Inhibitor Engineered to Induce a Tandem Blockade of the Epidermal Growth Factor Receptor (EGFR) and c-Src: The Concept of Type III Combi-Targeting","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Regional Health Centre; Royal Victoria Hospital","funders":"Canadian Institutes of Health Research; Servier; McGill University Health Centre; McGill University","keywords":"Proto-oncogene tyrosine-protein kinase Src; Dasatinib; Kinase; Cancer research; Tyrosine kinase; Cell biology; Chemistry; Phosphorylation; EGFR inhibitors; SH3 domain; Tyrosine-kinase inhibitor; Epidermal growth factor receptor; Biology; Signal transduction; Biochemistry; Receptor; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009568507,0.0003118044,0.0002054476,0.0001145325,0.00007053836,0.0002813192,0.0002125659,0.0002591155,0.0005695834],"category_scores_gemma":[0.00006880262,0.0001213039,0.0002562079,0.0001008771,0.0001509584,0.0002246365,0.000166824,0.0003940783,0.000312112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002072237,"about_ca_system_score_gemma":0.0001296713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001291287,"about_ca_topic_score_gemma":0.0002285797,"domain_scores_codex":[0.9999011,0.00001169318,0.00001024448,0.00002623063,0.00002914101,0.00002167339],"domain_scores_gemma":[0.9999475,0.000004526281,0.00002759218,0.000004896775,0.000005217136,0.00001025653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005279147,0.00002902456,0.00006928953,0.00002639205,0.000007198868,0.00003945973,0.000007400602,0.0001271341,0.9978969,0.0001462332,0.00002747193,0.001570541],"study_design_scores_gemma":[0.00001930866,0.0003560829,0.0004210846,0.000001274474,0.00001335468,0.0002200659,0.000004602029,0.0007691314,0.9959872,0.00002134848,0.002182525,0.000004080498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853566,0.001172451,0.01059216,0.00008809367,0.00003385555,0.0001118749,0.0001936996,0.0001163065,0.002334927],"genre_scores_gemma":[0.9896078,0.0006040653,0.007342387,0.00006625358,0.00001024927,0.00006244424,0.0001616758,0.00001645293,0.00212868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005695834,"threshold_uncertainty_score":0.001905441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03186594421063559,"score_gpt":0.2232635314270348,"score_spread":0.1913975872163992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}