{"id":"W1983528535","doi":"10.1371/journal.pgen.1001162","title":"Pervasive Cryptic Epistasis in Molecular Evolution","year":2010,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Biology; Epistasis; Genetics; Mutant; Mutation; Phylogenetic tree; Molecular evolution; Escherichia coli; Phylogenetics; Wild type; Gene; Evolutionary biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000985819,0.0004216376,0.0004895059,0.0006533334,0.0004673581,0.0005651828,0.0003960631,0.0004715673,0.001405038],"category_scores_gemma":[0.001693202,0.0003177099,0.0003373609,0.0005093844,0.000657361,0.0004328176,0.0009257302,0.000749978,0.0002206606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006085853,"about_ca_system_score_gemma":0.0004990945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005928577,"about_ca_topic_score_gemma":0.002136132,"domain_scores_codex":[0.9988722,0.0003280649,0.00007851055,0.0002911099,0.0002979494,0.0001321709],"domain_scores_gemma":[0.9991422,0.0002980464,0.0001561401,0.000201193,0.0000948185,0.0001076681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003358405,0.0000818003,0.02283067,0.000155432,0.0001917059,0.0008902927,0.0002426771,0.002530196,0.93581,0.007132021,0.000167265,0.02963229],"study_design_scores_gemma":[0.0002656866,0.002237529,0.5811412,0.00007084072,0.0007788918,0.02186608,0.001010833,0.05592864,0.2720196,0.04196545,0.02239801,0.000317234],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844127,0.0003643367,0.01296796,0.0001226716,0.0000108931,0.00002779633,0.00007025967,0.0001301899,0.001893182],"genre_scores_gemma":[0.9964399,0.00013236,0.002962589,0.0000552723,0.000005348315,0.00001168728,0.0000528856,0.0000155778,0.0003243747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001405038,"threshold_uncertainty_score":0.005213559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008080104311572196,"score_gpt":0.2177011929342623,"score_spread":0.2096210886226901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}