{"id":"W1983549722","doi":"10.1247/csf.06028","title":"pXBP1(U), a Negative Regulator of the Unfolded Protein Response Activator pXBP1(S), Targets ATF6 but not ATF4 in Proteasome-mediated Degradation","year":2009,"lang":"en","type":"article","venue":"Cell Structure and Function","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Education, Culture, Sports, Science and Technology; York University","keywords":"ATF6; XBP1; Unfolded protein response; Cell biology; Transcription factor; RNA splicing; ATF4; Endoplasmic reticulum; Proteasome; Biology; Molecular biology; Chemistry; Biochemistry; RNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001097272,0.0001707684,0.0001503024,0.00004739729,0.00009708467,0.00001699423,0.0000890953,0.0001864604,0.00001947039],"category_scores_gemma":[0.0002446113,0.0001220895,0.00006375414,0.000150255,0.0000794863,0.00001324518,0.00003334101,0.0001435142,5.936284e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002146209,"about_ca_system_score_gemma":0.00007660367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003151709,"about_ca_topic_score_gemma":0.00001954097,"domain_scores_codex":[0.9989699,0.0001804504,0.0002138553,0.0003095995,0.0001553465,0.0001708882],"domain_scores_gemma":[0.9994056,0.00002248641,0.0001773884,0.0002635237,0.00005608917,0.00007497818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003492404,0.00004441258,0.002332306,0.00002950489,0.00001250568,0.000001170663,0.00006352969,0.00003229959,0.991693,0.00002918859,0.0001750628,0.002094603],"study_design_scores_gemma":[0.001098001,0.00030025,0.2015999,0.00002650904,0.00001874957,0.000002280084,0.00008086249,0.00006743609,0.7956029,0.0004914263,0.0005886146,0.0001231584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984846,0.0002249138,0.0001045339,0.0002274516,0.00009254184,0.0007096833,0.00006654107,0.000008848057,0.00008091331],"genre_scores_gemma":[0.999122,0.00001877549,0.0001490266,0.0001451402,0.00007053107,0.00002693942,0.00008779885,0.00001076076,0.0003690249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1992676,"threshold_uncertainty_score":0.4978664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003629412183571004,"score_gpt":0.189950630030604,"score_spread":0.186321217847033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}