{"id":"W1983549722","doi":"10.1247/csf.06028","title":"pXBP1(U), a Negative Regulator of the Unfolded Protein Response Activator pXBP1(S), Targets ATF6 but not ATF4 in Proteasome-mediated Degradation","year":2009,"lang":"en","type":"article","venue":"Cell Structure and Function","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Education, Culture, Sports, Science and Technology; York University","keywords":"ATF6; XBP1; Unfolded protein response; Cell biology; Transcription factor; RNA splicing; ATF4; Endoplasmic reticulum; Proteasome; Biology; Molecular biology; Chemistry; Biochemistry; RNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001578986,0.0007008938,0.0003755845,0.0002238249,0.0004147704,0.0003762371,0.0002386441,0.0002238785,0.001822841],"category_scores_gemma":[0.0001238736,0.0002029415,0.0003106055,0.0002568568,0.0002785669,0.0002052567,0.0003753722,0.0004730808,0.0009225937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003264946,"about_ca_system_score_gemma":0.0002018829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003877588,"about_ca_topic_score_gemma":0.0002739587,"domain_scores_codex":[0.9998777,0.00001577426,0.000008888029,0.00005147566,0.0000269739,0.00001916415],"domain_scores_gemma":[0.9999248,0.000007117786,0.00002441417,0.000009466504,0.00001568517,0.00001849809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001674062,0.00002562328,0.0008860585,0.0001153447,0.00001160022,0.0001387522,0.00002323353,0.0001237239,0.9873313,0.0003145075,0.00039396,0.01046841],"study_design_scores_gemma":[0.00002565204,0.0002336695,0.01499544,0.00001801174,0.00003130522,0.001504185,0.00004073215,0.001454549,0.9646642,0.0002118561,0.01680938,0.0000111236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.94395,0.02364405,0.02567774,0.0003626406,0.0002259543,0.00007066548,0.001738477,0.000653489,0.003676903],"genre_scores_gemma":[0.969808,0.007074175,0.008097486,0.000149668,0.0000540567,0.00007880459,0.003684524,0.00007860366,0.01097462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001822841,"threshold_uncertainty_score":0.006097972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003629412183571004,"score_gpt":0.189950630030604,"score_spread":0.186321217847033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}