{"id":"W1983585455","doi":"10.1006/bbrc.2001.5861","title":"Human Aryl Hydrocarbon Receptor Polymorphisms That Result in Loss of CYP1A1 Induction","year":2001,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute","keywords":"Aryl hydrocarbon receptor; Linkage disequilibrium; Carcinogen; Biology; Subfamily; Genotype; Genetics; Receptor; Transcription factor; Haplotype; Xenobiotic; Polymorphism (computer science); In vitro; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003995558,0.0001151233,0.0001617968,0.0001063685,0.0001560779,0.00002112779,0.0004843629,0.0001719346,0.00001037118],"category_scores_gemma":[0.00009866741,0.0001058072,0.00007205723,0.0003830447,0.0007750429,0.000006546577,0.0005610883,0.0003386609,0.000004477199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003600269,"about_ca_system_score_gemma":0.00005439377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004201054,"about_ca_topic_score_gemma":0.00007292614,"domain_scores_codex":[0.9987295,0.0001380606,0.000232891,0.000314428,0.0002972823,0.0002877998],"domain_scores_gemma":[0.998739,0.00005206986,0.00005338838,0.0008986153,0.0001308839,0.0001260352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000716406,0.0004407925,0.002702253,0.00001101602,0.00001547455,8.38903e-7,0.00003685837,4.40164e-7,0.9942394,0.0009043053,0.0005366708,0.00104026],"study_design_scores_gemma":[0.0005061353,0.0003110076,0.02154908,0.00004368659,0.000006512963,0.000006326718,0.000148639,0.00006904753,0.971094,0.0007064731,0.005397798,0.000161261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996085,0.0007475025,0.00001375796,0.002080078,0.00001414056,0.0002082742,0.00002729099,0.000006638794,0.0008173077],"genre_scores_gemma":[0.9973568,0.001713331,0.0003284959,0.0000367517,0.0001028691,0.00004970743,0.0002072926,0.00001148262,0.0001932826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02314541,"threshold_uncertainty_score":0.4314693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07979427251157228,"score_gpt":0.373014477992328,"score_spread":0.2932202054807557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}