{"id":"W1983590366","doi":"10.1371/journal.pgen.1004669","title":"Germline Mutations in MAP3K6 Are Associated with Familial Gastric Cancer","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; McGill University; Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Queen Elizabeth II Health Sciences Centre; University of British Columbia; Princess Margaret Cancer Centre; Izaak Walton Killam Health Centre; Dalhousie University","funders":"Fundação para a Ciência e a Tecnologia; Health Canada; IWK Health Centre; Dalhousie University; Genome Atlantic; Nova Scotia Health Research Foundation; Genome Canada","keywords":"Biology; Germline mutation; Cancer; Genetics; Germline; CDH1; Cancer research; Gene; Point mutation; Mutation; DNA methylation; Somatic cell; Gene expression; Cell; Cadherin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001094689,0.0009115926,0.0003256506,0.001058338,0.0009218169,0.0002948191,0.0004039882,0.000647117,0.003405375],"category_scores_gemma":[0.0006701653,0.0002339602,0.0003696106,0.001170084,0.0005462663,0.000107208,0.0004324991,0.0004397281,0.0004297505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005763892,"about_ca_system_score_gemma":0.0003744699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01918781,"about_ca_topic_score_gemma":0.01552355,"domain_scores_codex":[0.9997942,0.00001611898,0.00001704145,0.00004773898,0.00008292916,0.00004199809],"domain_scores_gemma":[0.9996847,0.00004297753,0.0001257792,0.0000184871,0.0000510438,0.00007714237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001096655,0.0001080538,0.7519963,0.0002167326,0.0002954014,0.1472723,0.001073843,0.0005036783,0.08054835,0.0003985795,0.001501798,0.01498829],"study_design_scores_gemma":[0.00003114396,0.00009703317,0.8594664,0.00003820097,0.0001732562,0.1277518,0.0003501673,0.0006813179,0.007995635,0.0002252149,0.003169736,0.00002012674],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960569,0.001012844,0.0004275795,0.0001278991,0.00002013428,0.00002000227,0.0004363923,0.0000596768,0.00183852],"genre_scores_gemma":[0.9987679,0.0002700824,0.0002322694,0.00003920126,0.00001507901,0.000002891433,0.0002097029,0.000006527514,0.0004563093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01918781,"threshold_uncertainty_score":0.03815222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01470677780881871,"score_gpt":0.2264066849786922,"score_spread":0.2116999071698735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}