{"id":"W1983590366","doi":"10.1371/journal.pgen.1004669","title":"Germline Mutations in MAP3K6 Are Associated with Familial Gastric Cancer","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; McGill University; Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Queen Elizabeth II Health Sciences Centre; University of British Columbia; Princess Margaret Cancer Centre; Izaak Walton Killam Health Centre; Dalhousie University","funders":"Fundação para a Ciência e a Tecnologia; Health Canada; IWK Health Centre; Dalhousie University; Genome Atlantic; Nova Scotia Health Research Foundation; Genome Canada","keywords":"Biology; Germline mutation; Cancer; Genetics; Germline; CDH1; Cancer research; Gene; Point mutation; Mutation; DNA methylation; Somatic cell; Gene expression; Cell; Cadherin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006680986,0.0001289414,0.0001404034,0.00004907588,0.00004083066,0.00001188379,0.0001162671,0.0001171103,0.00001808691],"category_scores_gemma":[0.00008772568,0.0001173838,0.00003029218,0.0001331186,0.00004132085,0.000001312009,0.0000397292,0.00007949257,0.000007637669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001948282,"about_ca_system_score_gemma":0.0000676883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001126862,"about_ca_topic_score_gemma":0.001032413,"domain_scores_codex":[0.9991792,0.0000578647,0.0001563921,0.0002446545,0.0001276707,0.0002341712],"domain_scores_gemma":[0.9995304,0.00001456123,0.00008616943,0.0002117999,0.00008771665,0.00006932721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006017561,0.000313896,0.3401763,0.00002896985,0.000100604,0.00001158437,0.00009521089,0.002456357,0.6545542,0.00003656828,0.0007385879,0.001427479],"study_design_scores_gemma":[0.003837042,0.00136804,0.3477795,0.0001621267,0.0001742519,0.00001384782,0.0001447663,0.01214103,0.62512,0.0002167491,0.008184015,0.0008586473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980922,0.0003206266,0.000494932,0.00007094465,0.00007798299,0.0001433714,0.00006577529,0.00001346153,0.0007206444],"genre_scores_gemma":[0.9984469,0.00008523616,0.0004187551,0.0001879312,0.0002159186,0.00005055379,0.0001968338,0.00002518825,0.0003726307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02943428,"threshold_uncertainty_score":0.4786773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01470677780881871,"score_gpt":0.2264066849786922,"score_spread":0.2116999071698735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}