{"id":"W1983598477","doi":"10.1016/j.ydbio.2005.12.018","title":"Retinoic acid signaling is essential for formation of the heart tube in Xenopus","year":2006,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Heart and Stroke Foundation of Canada; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Directorate for Biological Sciences; National Institutes of Health","keywords":"Retinoic acid; Biology; Xenopus; Heart development; Cell biology; Retinoic acid receptor; Mesoderm; Morphogenesis; Embryonic heart; Endocrinology; Internal medicine; Embryonic stem cell; Genetics; Cell culture; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001725266,0.0003967877,0.0003522478,0.0005502318,0.0004788162,0.0009433635,0.0003410191,0.0004647286,0.001522294],"category_scores_gemma":[0.0002855863,0.0005653239,0.0003256437,0.0002050214,0.0005398582,0.0004707428,0.0003762328,0.0008978996,0.001059888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006794271,"about_ca_system_score_gemma":0.0004749476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001639633,"about_ca_topic_score_gemma":0.00255084,"domain_scores_codex":[0.9997858,0.00003868695,0.00003105573,0.00004656348,0.00005678929,0.00004104724],"domain_scores_gemma":[0.999511,0.0001136481,0.0001699794,0.00006907152,0.00003790558,0.00009834163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000901017,0.00000479225,0.0002258944,0.00002147905,0.000003400393,0.0001195708,0.00001834627,0.00009927543,0.9981172,0.0004561177,0.00002565876,0.0008181917],"study_design_scores_gemma":[0.0000157846,0.00005442934,0.003340899,0.00001093847,0.00001288056,0.0003922083,0.00003255234,0.0005346225,0.9927397,0.00009682337,0.002762996,0.00000618282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788169,0.004244552,0.009141522,0.0002823858,0.0000612529,0.0000263395,0.0008401169,0.0004341529,0.006152748],"genre_scores_gemma":[0.9841731,0.001459087,0.00577243,0.00005934572,0.00001604332,0.00002251193,0.00115386,0.0001934058,0.007150259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001639633,"threshold_uncertainty_score":0.005092621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080784147385272,"score_gpt":0.272798098923596,"score_spread":0.2619902574497433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}