{"id":"W1983598547","doi":"10.1038/gt.2010.71","title":"BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease","year":2010,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Multiple Sclerosis Society; Multiple Sclerosis Society of Canada; Fundació la Marató de TV3","keywords":"Quinolinate; Neurotrophic factors; Neuroprotection; Brain-derived neurotrophic factor; Glial fibrillary acidic protein; Astrocyte; Huntingtin; Biology; Genetically modified mouse; Gliosis; Transgene; Glial cell line-derived neurotrophic factor; Huntington's disease; Microglia; Internal medicine; Endocrinology; Pharmacology; Quinolinic acid; Immunology; Neuroscience; Medicine; Central nervous system; Inflammation; Biochemistry; Disease; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001334027,0.0002527453,0.0001690218,0.0001579144,0.0001267783,0.0001305765,0.0002399461,0.00007154445,0.00008252948],"category_scores_gemma":[0.0003323002,0.0002309367,0.00009963504,0.0002513471,0.00006563097,0.0002023223,0.00002861011,0.0001635531,0.00001593901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003059919,"about_ca_system_score_gemma":0.0002506875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001263534,"about_ca_topic_score_gemma":0.00001178686,"domain_scores_codex":[0.99831,0.0001179149,0.0002406451,0.0007090449,0.0002638723,0.0003584891],"domain_scores_gemma":[0.9991194,0.00005061632,0.0001110705,0.0004283898,0.00005834904,0.0002321509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004852991,0.0002453489,0.001651196,0.00003024345,0.000005153237,8.644244e-7,0.0001313907,0.002020826,0.986289,0.0001520845,0.00003804468,0.008950525],"study_design_scores_gemma":[0.001357721,0.0001608001,0.07627678,0.000008754276,0.00000893998,0.000003203942,0.000005050121,0.003164252,0.9178341,0.000845184,0.0001113547,0.0002238366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9636552,0.00003762159,0.03232719,0.000618454,0.0001743906,0.003034056,0.00001051406,0.0001149447,0.00002766482],"genre_scores_gemma":[0.9940214,0.00001392376,0.003471599,0.000483272,0.0003350657,0.0007886119,0.0000297198,0.0000612865,0.0007951558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07462558,"threshold_uncertainty_score":0.9417325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04067587129418374,"score_gpt":0.2753190214075541,"score_spread":0.2346431501133704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}