{"id":"W1983598547","doi":"10.1038/gt.2010.71","title":"BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease","year":2010,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Multiple Sclerosis Society; Multiple Sclerosis Society of Canada; Fundació la Marató de TV3","keywords":"Quinolinate; Neurotrophic factors; Neuroprotection; Brain-derived neurotrophic factor; Glial fibrillary acidic protein; Astrocyte; Huntingtin; Biology; Genetically modified mouse; Gliosis; Transgene; Glial cell line-derived neurotrophic factor; Huntington's disease; Microglia; Internal medicine; Endocrinology; Pharmacology; Quinolinic acid; Immunology; Neuroscience; Medicine; Central nervous system; Inflammation; Biochemistry; Disease; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001351802,0.0002299272,0.0002102623,0.0001186022,0.0001407726,0.0002388936,0.0001961492,0.0002647056,0.0003657833],"category_scores_gemma":[0.00007742196,0.0001201564,0.0001988452,0.00007266257,0.0001929838,0.0001895097,0.0001664814,0.0004103839,0.0001340299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001295348,"about_ca_system_score_gemma":0.0001774679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005351951,"about_ca_topic_score_gemma":0.0009959385,"domain_scores_codex":[0.9999166,0.00001390623,0.00001047968,0.00001611734,0.00002496048,0.00001797055],"domain_scores_gemma":[0.9999418,0.00001023945,0.00001690797,0.000007361004,0.00000981377,0.00001389054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007033662,0.00001250561,0.00003914864,0.00001276835,0.00000187261,0.00003781329,0.00001006204,0.00002637752,0.9989657,0.0001265046,0.00001463823,0.0006822064],"study_design_scores_gemma":[0.00001123642,0.0001161517,0.000521648,0.000002319646,0.00001781399,0.0001832777,0.00001116519,0.0004215361,0.9975373,0.00005218569,0.001122654,0.000002824669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855257,0.001292374,0.01161763,0.0001374681,0.00006595224,0.000021816,0.0001325772,0.0001313614,0.001075164],"genre_scores_gemma":[0.9894394,0.001004149,0.006750994,0.00003929012,0.00001767036,0.00002629224,0.000129814,0.00004861191,0.002543782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005351951,"threshold_uncertainty_score":0.001223683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04067587129418374,"score_gpt":0.2753190214075541,"score_spread":0.2346431501133704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}