{"id":"W1983605196","doi":"10.1002/dneu.22031","title":"A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice","year":2012,"lang":"en","type":"article","venue":"Developmental Neurobiology","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research","keywords":"Cilium; Ciliopathy; Biology; Bardet–Biedl syndrome; Intraflagellar transport; Ciliopathies; Ciliogenesis; Cell biology; Neuroscience; Motile cilium; Knockout mouse; Phenotype; Endocrinology; Internal medicine; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002100975,0.00088259,0.0004846176,0.001356944,0.0003623147,0.0004686188,0.0005977525,0.001218207,0.00379805],"category_scores_gemma":[0.0002521064,0.0005316409,0.000674489,0.0003623916,0.0007270846,0.0002691674,0.0004482084,0.001472101,0.0008860408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005659307,"about_ca_system_score_gemma":0.0003452919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001552349,"about_ca_topic_score_gemma":0.001852323,"domain_scores_codex":[0.9996626,0.00003067405,0.00005711636,0.0001001552,0.00008231009,0.00006712849],"domain_scores_gemma":[0.9993488,0.00007999479,0.000233964,0.00004420615,0.0000265985,0.0002664833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003296949,0.00007843827,0.0002406734,0.00003161314,0.0000134708,0.0001302174,0.00002730788,0.00009297735,0.9979697,0.0001225137,0.00005630038,0.0009070814],"study_design_scores_gemma":[0.0002463361,0.001293033,0.02302532,0.00004913683,0.0001370587,0.001314801,0.0001966024,0.003443555,0.965632,0.0002854616,0.004336176,0.000040501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939681,0.0007538254,0.00235598,0.000216377,0.00006144602,0.00003659611,0.001454143,0.0003146376,0.0008387997],"genre_scores_gemma":[0.9897279,0.0008000439,0.002677815,0.0001846116,0.00004164937,0.00009971289,0.001310959,0.0002021671,0.004955085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00379805,"threshold_uncertainty_score":0.01270568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015836006000461,"score_gpt":0.2477735716720684,"score_spread":0.2376152116120638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}