{"id":"W1983613739","doi":"10.1016/j.bpj.2013.11.3752","title":"Applying Osmotic Stress Reveals Two Modes of Enzyme Inhibition","year":2014,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Royal University","funders":"","keywords":"Osmolyte; Chemistry; Steric effects; Enzyme; Osmotic shock; Product inhibition; Betaine; Substrate (aquarium); Polyethylene glycol; Hydrolysis; Alkaline phosphatase; Aqueous solution; Phosphatase; Biochemistry; Non-competitive inhibition; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003709325,0.0007263771,0.0006090222,0.0002357392,0.0002294207,0.0009329226,0.000768156,0.0007910554,0.002162299],"category_scores_gemma":[0.0008943199,0.0004451609,0.0004296352,0.000257207,0.0008769183,0.0008192736,0.000564767,0.001813637,0.0006011804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003784816,"about_ca_system_score_gemma":0.0003459835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005416057,"about_ca_topic_score_gemma":0.0003834265,"domain_scores_codex":[0.9994422,0.00005815789,0.00005488359,0.00009761856,0.0001632566,0.0001838886],"domain_scores_gemma":[0.9991699,0.000306028,0.0001496625,0.0001510981,0.0001118055,0.0001113509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004030142,0.00007381484,0.0002410871,0.0000415525,0.00001029659,0.00006474307,0.00004929087,0.0000404722,0.9962901,0.0003701325,0.00005169768,0.002363859],"study_design_scores_gemma":[0.00002714294,0.0001394915,0.003851821,0.000003444784,0.0000106451,0.00015733,0.00003452508,0.0007924602,0.9942206,0.0001960074,0.0005554992,0.00001108637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9514126,0.001615942,0.0342635,0.000827887,0.0001626459,0.0001519022,0.0005038374,0.0005770732,0.01048451],"genre_scores_gemma":[0.9923826,0.0003781875,0.004006977,0.000185515,0.00003145447,0.00007497292,0.0001505553,0.00006412767,0.002725523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002162299,"threshold_uncertainty_score":0.00723362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02845638026057391,"score_gpt":0.3297772949232203,"score_spread":0.3013209146626464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}