{"id":"W1983624151","doi":"10.1039/c4mt00315b","title":"Iron-dependent turnover of IRP-1/c-aconitase in kidney cells","year":2015,"lang":"en","type":"article","venue":"Metallomics","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aconitase; Chemistry; Kidney; Cell biology; Protein turnover; Glutamate receptor; Biochemistry; Biology; Protein biosynthesis; Mitochondrion; Endocrinology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000174514,0.00008712832,0.0001160669,0.000038895,0.000007807959,0.000004885835,0.00009494968,0.0001033666,0.00001894232],"category_scores_gemma":[0.00001791857,0.00008407448,0.00005600675,0.00004980938,0.00003281521,0.000003607738,0.00002363635,0.00004395446,0.000007816584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001336141,"about_ca_system_score_gemma":0.000083409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002727486,"about_ca_topic_score_gemma":0.00004427635,"domain_scores_codex":[0.9994155,0.00001951219,0.0001862742,0.0001511029,0.0001089651,0.0001187015],"domain_scores_gemma":[0.9996189,0.00000181429,0.00005955219,0.000175526,0.00005057593,0.00009363895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001345604,0.00009380098,0.002231442,0.00002953097,0.00002115814,0.000004518346,0.0001153918,0.001173996,0.9952888,0.0001104553,0.0006083467,0.0001879584],"study_design_scores_gemma":[0.001160556,0.0001195572,0.001252328,0.00001074859,0.0000216168,0.000002972268,0.0001026224,0.0001722042,0.9853863,0.0001702062,0.01145747,0.0001434679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977285,0.0001917096,0.0006630279,0.00004426496,0.0002624696,0.00008877733,0.00003132005,0.000003651963,0.0009863274],"genre_scores_gemma":[0.9983258,0.00003481683,0.000345128,0.00009528112,0.00007622795,0.000004124275,0.0002008115,0.00001226132,0.0009055978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01084912,"threshold_uncertainty_score":0.3428458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01410869146608201,"score_gpt":0.2291457658521124,"score_spread":0.2150370743860304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}