{"id":"W1983650071","doi":"10.1002/btpr.9","title":"CHO cells adapted to hypothermic growth produce high yields of recombinant β‐interferon","year":2008,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chinese hamster ovary cell; Recombinant DNA; Subculture (biology); Microcarrier; Titer; Cell culture; Cell growth; Interferon; Population; Biology; Doubling time; Growth rate; Chemistry; Molecular biology; Biochemistry; Immunology; Antibody; Microbiology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001619037,0.000286882,0.0003207227,0.0001398038,0.0001452577,0.0003120459,0.0001827961,0.0001731813,0.0006866048],"category_scores_gemma":[0.0001202685,0.0001273102,0.0002735745,0.0001546367,0.0001441515,0.0001489572,0.000311987,0.000465002,0.0005767846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002252524,"about_ca_system_score_gemma":0.0001228503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004257342,"about_ca_topic_score_gemma":0.0006178904,"domain_scores_codex":[0.9999146,0.00001211695,0.00001287134,0.00002035578,0.0000245297,0.0000154935],"domain_scores_gemma":[0.9999232,0.00001444766,0.00001802215,0.00001852486,0.00001489055,0.00001094121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001458935,0.000003064208,0.0001012714,0.000006413341,0.000001874349,0.00001061938,0.000008589097,0.000009099093,0.9994006,0.00001449013,0.00000829493,0.0004210493],"study_design_scores_gemma":[0.00001285337,0.0001560857,0.00748043,0.000005245273,0.00002494393,0.0002598898,0.00002947776,0.0003038544,0.9884713,0.0000505499,0.003198686,0.000006626734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872918,0.0009671468,0.00817594,0.00007387761,0.00003622454,0.00006189872,0.0004660545,0.00009817118,0.002828873],"genre_scores_gemma":[0.9814374,0.000882816,0.01149348,0.000096735,0.00001854701,0.00008835517,0.001762484,0.00006829877,0.00415189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006866048,"threshold_uncertainty_score":0.002296984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076789402062863,"score_gpt":0.2292050705463222,"score_spread":0.2184371765256936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}