{"id":"W1983650071","doi":"10.1002/btpr.9","title":"CHO cells adapted to hypothermic growth produce high yields of recombinant β‐interferon","year":2008,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chinese hamster ovary cell; Recombinant DNA; Subculture (biology); Microcarrier; Titer; Cell culture; Cell growth; Interferon; Population; Biology; Doubling time; Growth rate; Chemistry; Molecular biology; Biochemistry; Immunology; Antibody; Microbiology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007383312,0.0002075118,0.0002370209,0.0001321853,0.0001065903,0.000007364372,0.0003849783,0.0004960194,0.00003086508],"category_scores_gemma":[0.00006216731,0.0001845063,0.00009896703,0.0002208936,0.0002933727,0.000003958771,0.000261492,0.0001382526,0.00002858691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001535534,"about_ca_system_score_gemma":0.00005871475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004318545,"about_ca_topic_score_gemma":0.000007559078,"domain_scores_codex":[0.998713,0.00004424214,0.000271151,0.000528713,0.0001112571,0.0003316949],"domain_scores_gemma":[0.9990376,0.000005724243,0.000136125,0.0006071671,0.0001195839,0.00009383049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002872415,0.0003360413,0.001931294,0.00003512846,0.0000623026,0.00001479894,0.00002781858,0.00001232761,0.9782314,0.0002641907,0.01359486,0.005202577],"study_design_scores_gemma":[0.0004529356,0.001796521,0.001368804,0.00003913531,0.0000130445,0.00004693602,0.00001555643,0.000006004165,0.980992,0.0001010477,0.01494109,0.0002269019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963975,0.0007969453,0.000364146,0.0009739003,0.000689538,0.0005511175,0.00001683563,0.00009094994,0.000119048],"genre_scores_gemma":[0.9974517,0.000372906,0.001099112,0.00017189,0.0001012562,0.0001355257,0.00001989565,0.00003319755,0.0006144796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004975675,"threshold_uncertainty_score":0.752395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076789402062863,"score_gpt":0.2292050705463222,"score_spread":0.2184371765256936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}