{"id":"W1983688844","doi":"10.1016/j.brainres.2010.09.099","title":"Progranulin deficiency leads to enhanced cell vulnerability and TDP-43 translocation in primary neuronal cultures","year":2010,"lang":"en","type":"article","venue":"Brain Research","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Fondation pour la Recherche sur Alzheimer; Pacific Alzheimer Research Foundation; McGill University","keywords":"Chromosomal translocation; Vulnerability (computing); Cell; Biology; Cell biology; Neuroscience; Genetics; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004555688,0.0007275618,0.001098707,0.0009372471,0.0006548826,0.0008318012,0.0006925236,0.0007161775,0.002117532],"category_scores_gemma":[0.0003258472,0.0004577881,0.0008579845,0.000702937,0.0004842867,0.0005664115,0.0007438879,0.001719005,0.00126727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00078269,"about_ca_system_score_gemma":0.0006276327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005498831,"about_ca_topic_score_gemma":0.006007686,"domain_scores_codex":[0.9993142,0.00008589366,0.0001311227,0.0001224051,0.0001635907,0.0001828397],"domain_scores_gemma":[0.9993823,0.0002088498,0.00005992025,0.0001058855,0.00007304443,0.0001700502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003782455,0.00008095054,0.0002483239,0.00005555792,0.00003082468,0.0005918181,0.0001118584,0.00009078853,0.9976308,0.0001421213,0.00009779093,0.0005408938],"study_design_scores_gemma":[0.0000360652,0.0003408795,0.004833934,0.0000118898,0.00007251234,0.0009454281,0.0001595496,0.0007427961,0.9915054,0.0001191698,0.001220602,0.00001183255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928274,0.001562736,0.001609642,0.0001501177,0.00007679089,0.00003530621,0.001112164,0.0001070012,0.002518873],"genre_scores_gemma":[0.9893912,0.001296535,0.002217938,0.0000622657,0.00002328864,0.00008731861,0.001528426,0.00006316975,0.005329809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005498831,"threshold_uncertainty_score":0.01093364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04446152408436313,"score_gpt":0.3891022744753516,"score_spread":0.3446407503909885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}