{"id":"W1983693962","doi":"10.1021/jm5007275","title":"Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2","year":2014,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":211,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vertex Pharmaceuticals (Canada)","funders":"","keywords":"Potency; Virology; Chemistry; Influenza A virus; Influenza A virus subtype H5N1; Bioavailability; Orthomyxoviridae; Virus; Pharmacology; In vitro; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00168589,0.0002540976,0.001153279,0.0002302019,0.00004314736,0.00001191389,0.0003279784,0.0001936595,0.0001136346],"category_scores_gemma":[0.003919947,0.0001883456,0.0002528308,0.0004236922,0.0005346722,0.0002331915,0.0001407676,0.0008176339,0.000004073142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002308338,"about_ca_system_score_gemma":0.000664485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008251785,"about_ca_topic_score_gemma":0.0000119514,"domain_scores_codex":[0.9963258,0.00003985326,0.001486371,0.0002116991,0.001503661,0.0004326435],"domain_scores_gemma":[0.9971327,0.0004117848,0.001012485,0.000372725,0.0008368334,0.0002335015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003247124,0.0009417773,0.0518734,0.003514825,0.000329766,0.0001407231,0.0005711553,0.0001050117,0.9313912,0.00002549874,0.007152902,0.0007065777],"study_design_scores_gemma":[0.01842272,0.00209408,0.01845212,0.00759038,0.0003057643,0.0005116815,0.001633004,0.0002716852,0.9208564,0.00007431168,0.02947766,0.0003102183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908979,0.002818556,0.00008518151,0.0009999617,0.0001359026,0.0001584135,0.00001747624,0.000007117168,0.004879504],"genre_scores_gemma":[0.9970141,0.0003271466,0.0008571383,0.0003722354,0.0008356707,0.0000042347,0.000002436522,0.00002812983,0.0005588826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03342128,"threshold_uncertainty_score":0.7680509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04480615340995221,"score_gpt":0.3347052372622018,"score_spread":0.2898990838522496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}