{"id":"W1983693962","doi":"10.1021/jm5007275","title":"Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2","year":2014,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":211,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vertex Pharmaceuticals (Canada)","funders":"","keywords":"Potency; Virology; Chemistry; Influenza A virus; Influenza A virus subtype H5N1; Bioavailability; Orthomyxoviridae; Virus; Pharmacology; In vitro; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001163449,0.0003547095,0.0004047366,0.0002223739,0.0001333967,0.0003260815,0.0003535759,0.0002698849,0.001217093],"category_scores_gemma":[0.00009406146,0.00009985563,0.0002110293,0.0001025264,0.0001786446,0.0002983982,0.0001864742,0.000479542,0.0004033116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002779006,"about_ca_system_score_gemma":0.0002558927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004175257,"about_ca_topic_score_gemma":0.001329822,"domain_scores_codex":[0.9999568,0.000006573539,0.000002654798,0.000009961394,0.0000108726,0.00001319524],"domain_scores_gemma":[0.999969,0.000005336023,0.000006690231,0.000001993899,0.000006398894,0.00001059789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003781408,0.0002853009,0.0006538755,0.000263477,0.00003897402,0.0006474461,0.00007408882,0.0009655026,0.9613884,0.001113739,0.000834219,0.0333569],"study_design_scores_gemma":[0.0007397722,0.008007397,0.004835463,0.00006149152,0.0001384406,0.002440141,0.00009289397,0.004283261,0.9475363,0.0005060078,0.03131728,0.00004155268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9591483,0.01516057,0.01405467,0.0008477803,0.0001426009,0.0004180028,0.001308231,0.000256768,0.008663008],"genre_scores_gemma":[0.9724505,0.01010141,0.009681241,0.0003433029,0.00005888514,0.0001379973,0.001608839,0.00002895678,0.005588911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001217093,"threshold_uncertainty_score":0.004071593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04480615340995221,"score_gpt":0.3347052372622018,"score_spread":0.2898990838522496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}