{"id":"W1983695933","doi":"10.1074/jbc.m602931200","title":"An Active Nuclear Retention Signal in the Glucocorticoid Receptor Functions as a Strong Inducer of Transcriptional Activation","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Providence Health Care; University of Ottawa","funders":"","keywords":"Nuclear export signal; Karyopherin; Nuclear transport; Importin; Nuclear localization sequence; Glucocorticoid receptor; Biology; Nuclear receptor; Ectopic expression; Repressor; Nuclear receptor coactivator 2; Cell nucleus; Cell biology; Transcription factor; Nuclear receptor coactivator 1; Nuclear receptor co-repressor 1; Cytoplasm; Receptor; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003880529,0.00009200982,0.0001237526,0.00002961292,0.00003999212,0.00001051433,0.0001458887,0.0002461596,0.000284724],"category_scores_gemma":[0.00006945913,0.00006072518,0.000126205,0.0001034466,0.00006972695,0.00001660492,0.00001074267,0.0002782429,0.000002073763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002975078,"about_ca_system_score_gemma":0.00004134972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002841272,"about_ca_topic_score_gemma":9.743088e-7,"domain_scores_codex":[0.999182,0.0000556647,0.000332815,0.0001373352,0.000168805,0.000123338],"domain_scores_gemma":[0.9994254,0.00002332782,0.0002665897,0.0001102693,0.00012992,0.00004455892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001267868,0.0001416382,0.001361013,0.000007440493,0.00003117737,0.000001546433,0.00007021909,0.00003438444,0.9933825,0.00004055026,0.00008235098,0.003579275],"study_design_scores_gemma":[0.0006837739,0.001300205,0.07565567,0.00002183147,0.00002081454,0.00008999478,0.002545939,0.00001192771,0.9150665,0.0001300159,0.004364848,0.0001084878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977757,0.00003369647,0.0009044681,0.00008686023,0.00008593803,0.00006881711,0.000007313128,0.000002456982,0.001034713],"genre_scores_gemma":[0.9991645,0.00002188414,0.00019972,0.0001079661,0.0004060799,9.140763e-7,0.00006346159,0.000006525167,0.00002890803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07831605,"threshold_uncertainty_score":0.3117528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01930823667830086,"score_gpt":0.2560044910637658,"score_spread":0.2366962543854649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}