{"id":"W1983699546","doi":"10.1074/jbc.m109.096453","title":"Proteolysis-induced N-terminal Ectodomain Shedding of the Integral Membrane Glycoprotein CUB Domain-containing Protein 1 (CDCP1) Is Accompanied by Tyrosine Phosphorylation of Its C-terminal Domain and Recruitment of Src and PKCδ","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Ectodomain; Proteolysis; Proto-oncogene tyrosine-protein kinase Src; Phosphorylation; Tyrosine; Terminal (telecommunication); Glycoprotein; Tyrosine phosphorylation; Cell biology; Integral membrane protein; Chemistry; Domain (mathematical analysis); Protein tyrosine phosphatase; Biochemistry; Membrane; Membrane protein; Biology; Computer science; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008702329,0.0002323772,0.0008206082,0.00007184958,0.00006957433,0.00001517298,0.0001659632,0.000276882,0.0001973073],"category_scores_gemma":[0.0003016822,0.0001374851,0.0002823107,0.0002263285,0.0003175738,0.00007753564,0.00009491338,0.000631834,2.016688e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004702117,"about_ca_system_score_gemma":0.0000928252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009830722,"about_ca_topic_score_gemma":0.00000124484,"domain_scores_codex":[0.9980413,0.00009138852,0.001027821,0.0002442452,0.0003912355,0.0002040058],"domain_scores_gemma":[0.9979574,0.00008214571,0.001313895,0.0002056811,0.0002746438,0.0001662099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001232326,0.0002323144,0.003124898,0.0003197153,0.0001286614,0.00003220302,0.0002204899,2.926584e-7,0.9934419,0.00002511918,0.00001222485,0.001229856],"study_design_scores_gemma":[0.002390443,0.0006677178,0.003898177,0.001433422,0.0001255282,0.000527041,0.0004699462,0.00006280507,0.9899932,0.0002567313,0.00004382651,0.0001311232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984436,0.0002037892,0.00005042886,0.0005515377,0.00001464227,0.0005207607,0.0000305149,0.000005895884,0.0001788481],"genre_scores_gemma":[0.9974337,0.00002245478,0.002292559,0.00006302262,0.00009666974,0.00001506024,0.000009042036,0.000009963834,0.00005747628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003448661,"threshold_uncertainty_score":0.5606479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0305080743604163,"score_gpt":0.2869631813261613,"score_spread":0.256455106965745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}