{"id":"W1983701937","doi":"10.1002/ijc.24485","title":"Constitutively active MEK1 is sufficient to induce epithelial‐to‐mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis","year":2009,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Epithelial–mesenchymal transition; Metastasis; Cancer research; Transition (genetics); Cell biology; Biology; Epithelium; Mesenchymal stem cell; Chemistry; Pathology; Medicine; Cancer; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001698667,0.0003858393,0.0003118478,0.000276795,0.0001343173,0.0003172495,0.0002104458,0.0002331977,0.001715304],"category_scores_gemma":[0.0001802489,0.0002683526,0.0002848412,0.0001414385,0.0002163202,0.000203949,0.0002361279,0.0006134643,0.0005661675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000359521,"about_ca_system_score_gemma":0.0003191482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006743059,"about_ca_topic_score_gemma":0.0009954197,"domain_scores_codex":[0.9997573,0.00004584098,0.00003050367,0.00002692222,0.00006389128,0.00007551775],"domain_scores_gemma":[0.9996679,0.00008067309,0.00006348496,0.00004202916,0.00002463078,0.0001211989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000145458,0.00007604714,0.0001751666,0.00004191332,0.000005903652,0.00005434103,0.00001121313,0.00004766808,0.9987853,0.00008291053,0.00003737017,0.0005366603],"study_design_scores_gemma":[0.00004066866,0.0005967533,0.007364722,0.00000806042,0.00001724279,0.0003667143,0.00003421292,0.001474523,0.9872995,0.00004933176,0.002741541,0.000006552912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962897,0.0009730578,0.001136684,0.00007108395,0.00002594831,0.00002743025,0.0004788447,0.00008570911,0.0009114952],"genre_scores_gemma":[0.9945042,0.0005467071,0.001212314,0.00002596705,0.000009011725,0.00004841753,0.001461925,0.00002126096,0.002170203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001715304,"threshold_uncertainty_score":0.005738258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02126785029260254,"score_gpt":0.3194847626053189,"score_spread":0.2982169123127164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}