{"id":"W1983701937","doi":"10.1002/ijc.24485","title":"Constitutively active MEK1 is sufficient to induce epithelial‐to‐mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis","year":2009,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Epithelial–mesenchymal transition; Metastasis; Cancer research; Transition (genetics); Cell biology; Biology; Epithelium; Mesenchymal stem cell; Chemistry; Pathology; Medicine; Cancer; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003582677,0.0001768118,0.0003808654,0.000585201,0.00003374718,0.00004970522,0.0001266079,0.00003742299,0.0001126064],"category_scores_gemma":[0.0001464458,0.0001479687,0.00008206588,0.0002708516,0.00005095263,0.0001682067,0.00004183665,0.0002484561,0.00000630687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003579947,"about_ca_system_score_gemma":0.0003662766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003130762,"about_ca_topic_score_gemma":0.0001488336,"domain_scores_codex":[0.9984002,0.00003907799,0.0004711433,0.0002704655,0.000612538,0.0002065428],"domain_scores_gemma":[0.9986644,0.00004433954,0.0002142752,0.00007394727,0.0006120683,0.0003909142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005113002,0.000320171,0.0004199673,0.00002269447,0.0001954229,0.0004124227,0.007520084,0.0004691819,0.7113786,0.0001751889,0.0005569322,0.2734164],"study_design_scores_gemma":[0.003961381,0.002391453,0.04233195,0.001373103,0.000244627,0.0008189803,0.0006504254,0.00007211107,0.9192606,0.0002494511,0.02836165,0.0002842544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767003,0.0002381824,0.002865939,0.01879338,0.000513237,0.0004343465,0.0002844478,0.00000539781,0.0001647685],"genre_scores_gemma":[0.9879829,0.000211571,0.004525241,0.006839742,0.0003746716,0.00001141011,0.000001871308,0.0000106966,0.00004189827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2731321,"threshold_uncertainty_score":0.6033989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02126785029260254,"score_gpt":0.3194847626053189,"score_spread":0.2982169123127164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}