{"id":"W1983718883","doi":"10.1021/bi010555m","title":"A Polyalanine-Based Peptide Cannot Form a Stable Transmembrane α-Helix in Fully Hydrated Phospholipid Bilayers","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Research Council Canada; University of Alberta","keywords":"Chemistry; Phospholipid; Amide; Lipid bilayer; Crystallography; Helix (gastropod); Phosphatidylcholine; Peptide; Aqueous solution; Transmembrane protein; Bilayer; Stereochemistry; Membrane; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001509591,0.0003901832,0.0003043907,0.00007470017,0.00007891808,0.00004151309,0.0003555772,0.0004045115,0.0002439777],"category_scores_gemma":[0.00004587895,0.0003742299,0.0001751407,0.0003680727,0.0001052118,0.000008390728,0.00004695054,0.0002324427,0.00001427538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007037858,"about_ca_system_score_gemma":0.0004288669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004409046,"about_ca_topic_score_gemma":0.0002543636,"domain_scores_codex":[0.9979854,0.00002642803,0.0004001129,0.0006841941,0.0002415743,0.0006622845],"domain_scores_gemma":[0.9989666,0.0000103596,0.0001039084,0.000606717,0.00009202227,0.0002203422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004493884,0.0001449538,0.005995864,0.00008049705,0.00002503956,0.00005217473,0.00003046787,0.00007146245,0.9913691,0.000001760047,0.001133373,0.0006459255],"study_design_scores_gemma":[0.002148652,0.0001380191,0.00138013,0.00004547094,0.00003571157,0.00007442,0.00007241575,0.00008106769,0.9716886,0.000003401521,0.02385021,0.0004819324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996048,0.0002871201,0.00006810373,0.0003060279,0.0001770917,0.0002568586,0.00009542882,0.00005011566,0.002711302],"genre_scores_gemma":[0.9946674,0.00007055051,0.000246726,0.0005813892,0.0003975705,0.00006650631,0.0006739388,0.00005607719,0.003239836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02271684,"threshold_uncertainty_score":0.999871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007293219697280575,"score_gpt":0.2283249460112508,"score_spread":0.2210317263139703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}