{"id":"W1983760939","doi":"10.1081/ncn-100001436","title":"SYNTHESIS OF 1-(2-DEOXY-β-<scp>D</scp>-RIBOFURANOSYL)-2,4-DIFLUORO-5-SUBSTITUTED-BENZENES<sup>*</sup>: “THYMINE REPLACEMENT” ANALOGS OF THYMIDINE FOR EVALUATION AS ANTICANCER AND ANTIVIRAL AGENTS","year":2001,"lang":"en","type":"article","venue":"Nucleosides Nucleotides & Nucleic Acids","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Thymidine kinase; Herpes simplex virus; Cytotoxicity; Chemistry; Virus; Cytotoxic T cell; Transfection; Vaccinia; MTT assay; Nucleoside analogue; Virology; Molecular biology; Biology; Stereochemistry; Nucleoside; In vitro; Gene; Biochemistry; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002080878,0.0007272922,0.001703677,0.0008479655,0.0003480166,0.0001076917,0.0005199441,0.0004299982,0.000911947],"category_scores_gemma":[0.003384845,0.0006762444,0.0005468434,0.001142136,0.0008859995,0.0006570035,0.0003009191,0.000429422,0.00008181905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000276027,"about_ca_system_score_gemma":0.0003696511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005779279,"about_ca_topic_score_gemma":0.0000689013,"domain_scores_codex":[0.9940414,0.000245331,0.001611942,0.001184938,0.001774017,0.001142308],"domain_scores_gemma":[0.9952325,0.001175431,0.000674199,0.001209351,0.001220417,0.0004881462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006716071,0.003067416,0.2901554,0.002906131,0.003165234,0.00015373,0.003948744,0.0003957035,0.4918667,0.00459326,0.01407463,0.178957],"study_design_scores_gemma":[0.02448413,0.005873171,0.3446093,0.003268278,0.005758819,0.0004255355,0.006086135,0.09534862,0.4300909,0.003102448,0.07956319,0.001389434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860133,0.001257952,0.0001223019,0.0005700696,0.0001538048,0.002594244,0.0002038435,0.0001473356,0.00893716],"genre_scores_gemma":[0.9927557,0.002727507,0.002804397,0.000336135,0.0002979011,0.0001703527,0.00009796693,0.0002029331,0.000607122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1775676,"threshold_uncertainty_score":0.9995689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03198728614183822,"score_gpt":0.3239344215606384,"score_spread":0.2919471354188002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}