{"id":"W1983760939","doi":"10.1081/ncn-100001436","title":"SYNTHESIS OF 1-(2-DEOXY-β-<scp>D</scp>-RIBOFURANOSYL)-2,4-DIFLUORO-5-SUBSTITUTED-BENZENES<sup>*</sup>: “THYMINE REPLACEMENT” ANALOGS OF THYMIDINE FOR EVALUATION AS ANTICANCER AND ANTIVIRAL AGENTS","year":2001,"lang":"en","type":"article","venue":"Nucleosides Nucleotides & Nucleic Acids","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Thymidine kinase; Herpes simplex virus; Cytotoxicity; Chemistry; Virus; Cytotoxic T cell; Transfection; Vaccinia; MTT assay; Nucleoside analogue; Virology; Molecular biology; Biology; Stereochemistry; Nucleoside; In vitro; Gene; Biochemistry; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009799908,0.0003226773,0.0001975021,0.00008978321,0.0001037138,0.0001340445,0.0002202444,0.00021271,0.001677555],"category_scores_gemma":[0.00009112317,0.000086582,0.000124671,0.0001332949,0.0000934453,0.0001434826,0.00008904568,0.0002511178,0.0007123591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002375852,"about_ca_system_score_gemma":0.0002078308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008279142,"about_ca_topic_score_gemma":0.001407647,"domain_scores_codex":[0.9999275,0.0000156599,0.00000664349,0.00001541153,0.00001537904,0.00001936725],"domain_scores_gemma":[0.9999497,0.000004269693,0.00001436915,0.000004910001,0.000009762432,0.00001696467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001107725,0.00002236599,0.0000663807,0.00005458016,0.000003162624,0.00003998814,0.00001245061,0.0002206385,0.9966304,0.0001849678,0.00008947949,0.002564823],"study_design_scores_gemma":[0.00002622299,0.0006409364,0.0008493308,0.000005747602,0.00001036343,0.0002344451,0.00001082773,0.0005405308,0.990791,0.00002582016,0.00685676,0.000008046629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9636503,0.005800749,0.01908432,0.0001397001,0.0001036476,0.0001753734,0.001589211,0.0002921358,0.00916453],"genre_scores_gemma":[0.9789449,0.001557361,0.0141683,0.0001087689,0.00001230533,0.00008883148,0.001283803,0.00003049177,0.003805226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001677555,"threshold_uncertainty_score":0.005611956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03198728614183822,"score_gpt":0.3239344215606384,"score_spread":0.2919471354188002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}