{"id":"W1983855055","doi":"10.1523/jneurosci.4247-12.2013","title":"Conditional Disruption of Calpain in the CNS Alters Dendrite Morphology, Impairs LTP, and Promotes Neuronal Survival following Injury","year":2013,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Memorial University of Newfoundland; Ottawa Hospital; University of Ottawa","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; Ministry of Education, Science and Technology","keywords":"Calpain; Neuroscience; Proteases; Biology; Hippocampal formation; Long-term potentiation; Calpastatin; Synaptic plasticity; Cell biology; Dendrite (mathematics); Central nervous system; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005326311,0.00006549314,0.00008932762,0.00005397838,0.00005813745,0.00002545175,0.0001238402,0.000041531,0.000005872959],"category_scores_gemma":[0.0002406741,0.00004471264,0.00007141363,0.000113364,0.0001742103,0.00002573025,0.00003381581,0.0001093386,3.611286e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006287942,"about_ca_system_score_gemma":0.00003899055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000868209,"about_ca_topic_score_gemma":0.000002932511,"domain_scores_codex":[0.9991398,0.0001786943,0.0002398568,0.000122985,0.0002127961,0.0001058874],"domain_scores_gemma":[0.9996148,0.00003512626,0.0001697267,0.00007806985,0.00005638108,0.00004588379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000294835,0.00004965377,0.01112702,0.000004820158,0.000002396407,0.00000573853,0.0000406746,0.000102466,0.9877332,0.0000321498,0.000196608,0.0006757568],"study_design_scores_gemma":[0.0005642101,0.0009836472,0.9701827,0.00002157508,0.00001245486,0.0002933927,0.0001870722,0.001353314,0.02517465,0.0003278994,0.0007985564,0.0001005481],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968765,0.00004050659,0.001656966,0.0009168017,0.0003701297,0.0001206736,0.000004485653,0.000001230885,0.00001275567],"genre_scores_gemma":[0.9993478,0.00002267804,0.00009206551,0.000427816,0.00007755744,0.000003681291,0.000003722381,0.00000376467,0.00002093462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9625586,"threshold_uncertainty_score":0.1823329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01272057449865657,"score_gpt":0.2663400863322041,"score_spread":0.2536195118335475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}